Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder
Abstract Background As a potential new treatment for overactive bladder (OAB), we investigated the feasibility of non-invasively activating multiple nerve targets in the lower leg. Methods In healthy participants, surface electrical stimulation (frequency = 20 Hz, pulse width = 200 μs) was used to t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-02-01
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| Series: | BMC Urology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12894-018-0322-y |
| _version_ | 1817990743993614336 |
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| author | Eshani Sharan Kelly Hunter Magdy Hassouna Paul B. Yoo |
| author_facet | Eshani Sharan Kelly Hunter Magdy Hassouna Paul B. Yoo |
| author_sort | Eshani Sharan |
| collection | DOAJ |
| description | Abstract Background As a potential new treatment for overactive bladder (OAB), we investigated the feasibility of non-invasively activating multiple nerve targets in the lower leg. Methods In healthy participants, surface electrical stimulation (frequency = 20 Hz, pulse width = 200 μs) was used to target the tibial nerve, saphenous nerve, medial plantar nerve, and lateral plantar nerve. At each location, the stimulation amplitude was increased to define the thresholds for evoking (1) cutaneous sensation, (2) target nerve recruitment and (3) maximum tolerance. Results All participants were able to tolerate stimulation amplitudes that were 2.1 ± 0.2 (range = 2.0 to 2.4) times the threshold for activating the target nerve. Conclusions Non-invasive electrical stimulation can activate neural targets at levels that are consistent with evoking bladder-inhibitory reflex mechanisms. Further work is needed to test the clinical effects of stimulating one or more neural targets in OAB patients. |
| first_indexed | 2024-04-14T01:03:43Z |
| format | Article |
| id | doaj.art-e0ee728e2c46458fbf3635ac81f65312 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-04-14T01:03:43Z |
| publishDate | 2018-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-e0ee728e2c46458fbf3635ac81f653122022-12-22T02:21:19ZengBMCBMC Urology1471-24902018-02-011811710.1186/s12894-018-0322-yCharacterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladderEshani Sharan0Kelly Hunter1Magdy Hassouna2Paul B. Yoo3Institute of Biomaterials and Biomedical Engineering, University of TorontoInstitute of Biomaterials and Biomedical Engineering, University of TorontoDivision of Urology, Toronto Western HospitalInstitute of Biomaterials and Biomedical Engineering, University of TorontoAbstract Background As a potential new treatment for overactive bladder (OAB), we investigated the feasibility of non-invasively activating multiple nerve targets in the lower leg. Methods In healthy participants, surface electrical stimulation (frequency = 20 Hz, pulse width = 200 μs) was used to target the tibial nerve, saphenous nerve, medial plantar nerve, and lateral plantar nerve. At each location, the stimulation amplitude was increased to define the thresholds for evoking (1) cutaneous sensation, (2) target nerve recruitment and (3) maximum tolerance. Results All participants were able to tolerate stimulation amplitudes that were 2.1 ± 0.2 (range = 2.0 to 2.4) times the threshold for activating the target nerve. Conclusions Non-invasive electrical stimulation can activate neural targets at levels that are consistent with evoking bladder-inhibitory reflex mechanisms. Further work is needed to test the clinical effects of stimulating one or more neural targets in OAB patients.http://link.springer.com/article/10.1186/s12894-018-0322-yTranscutaneous electrical nerve stimulationBladder neuromodulationOveractive bladderTibial nerveSaphenous nervePlantar nerve |
| spellingShingle | Eshani Sharan Kelly Hunter Magdy Hassouna Paul B. Yoo Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder BMC Urology Transcutaneous electrical nerve stimulation Bladder neuromodulation Overactive bladder Tibial nerve Saphenous nerve Plantar nerve |
| title | Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder |
| title_full | Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder |
| title_fullStr | Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder |
| title_full_unstemmed | Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder |
| title_short | Characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults: implications for non-invasive treatment of overactive bladder |
| title_sort | characterizing the transcutaneous electrical recruitment of lower leg afferents in healthy adults implications for non invasive treatment of overactive bladder |
| topic | Transcutaneous electrical nerve stimulation Bladder neuromodulation Overactive bladder Tibial nerve Saphenous nerve Plantar nerve |
| url | http://link.springer.com/article/10.1186/s12894-018-0322-y |
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