Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity

Fat-to-blood recirculation of partially dysfunctional PD-1+CD4 Tconv cells is associated with dysglycemia in human obesity

Summary: Obesity is characterized by the accumulation of T cells in insulin-sensitive tissues, including the visceral adipose tissue (VAT), that can interfere with the insulin signaling pathway eventually leading to insulin resistance (IR) and type 2 diabetes. Here, we found that PD-1+CD4 convention...

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Bibliographic Details
Main Authors: Anna Giovenzana, Eugenia Bezzecchi, Anita Bichisecchi, Sara Cardellini, Francesca Ragogna, Federica Pedica, Federica Invernizzi, Luigi Di Filippo, Valentina Tomajer, Francesca Aleotti, Giulia M. Scotti, Carlo Socci, Giovanni Cesana, Stefano Olmi, Marco J. Morelli, Massimo Falconi, Andrea Giustina, Chiara Bonini, Lorenzo Piemonti, Eliana Ruggiero, Alessandra Petrelli
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Health sciences
Obesity medicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224002530

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