Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A
This study was conducted to assess the levels of inflammatory factors and angiogenic factors in patients with severe hemophilia A and evaluate their diagnostic values for acute joint bleeding. This study included a total of 144 patients with severe hemophilia A. Of them, 66 had acute joint bleeding....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-01-01
|
| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/1076029619892683 |
| _version_ | 1819007452134244352 |
|---|---|
| author | Huijuan Xu PhD Ren Zhong PhD Kai Wang PhD Xuerong Li PhD Yanxia Zhao PhD Jian Jiang PhD Shaoyong Si PhD Lirong Sun PhD |
| author_facet | Huijuan Xu PhD Ren Zhong PhD Kai Wang PhD Xuerong Li PhD Yanxia Zhao PhD Jian Jiang PhD Shaoyong Si PhD Lirong Sun PhD |
| author_sort | Huijuan Xu PhD |
| collection | DOAJ |
| description | This study was conducted to assess the levels of inflammatory factors and angiogenic factors in patients with severe hemophilia A and evaluate their diagnostic values for acute joint bleeding. This study included a total of 144 patients with severe hemophilia A. Of them, 66 had acute joint bleeding. Ninety healthy volunteers were recruited as control. The levels of leukocytes, monocytes, platelets, hemoglobin, phagocyte migration inhibitory factor (MIF), plasminogen, fibrin/fibrinogen degradation products, d -dimer, and α2 antifibrinolytic enzyme were measured using hematology analyzer. Thrombomodulin, endostatin, intercellular adhesion molecule 1, and vascular endothelial growth factor (VEGF) were assessed using enzyme-linked immunosorbent assay. Logistic regression analysis was performed to analyze the factors affecting acute joint bleeding. Compared with healthy volunteers, the levels of leukocytes, C-reactive protein (CRP), MIF, and VEGF were significantly ( P < .05) elevated in the patients with severe hemophilia A and were significantly higher in patients with joint bleeding than in patients with nonbleeding ( P < .05). Multivariate analysis showed that CRP and VEGF were independent risk factors for acute joint bleeding ( P < .05). The area under the curve, sensitivity, and specificity of CRP for the diagnosis of acute joint bleeding were 0.829, 88.43%, and 67.87%, respectively, and those of VEGF were 0.758, 82.8%, and 68.3%, respectively. The levels of inflammatory factors and angiogenesis factors are elevated in patients with severe hemophilia A and both CRP and VEGF are closely related to acute joint bleeding and may be used as potential biomarkers for predicting acute joint bleeding in patients with severe hemophilia A. |
| first_indexed | 2024-12-21T00:24:48Z |
| format | Article |
| id | doaj.art-e0ef0ec86d9c4e95903fdb0e6150f418 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-12-21T00:24:48Z |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-e0ef0ec86d9c4e95903fdb0e6150f4182022-12-21T19:22:01ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232020-01-012610.1177/1076029619892683Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia AHuijuan Xu PhD0Ren Zhong PhD1Kai Wang PhD2Xuerong Li PhD3Yanxia Zhao PhD4Jian Jiang PhD5Shaoyong Si PhD6Lirong Sun PhD7 Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Emergency Surgery, Qingdao Hiser Medical Center, Qingdao, China Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, China Department of Pediatrics, The Affiliated Hospital of Qingdao University, Qingdao, ChinaThis study was conducted to assess the levels of inflammatory factors and angiogenic factors in patients with severe hemophilia A and evaluate their diagnostic values for acute joint bleeding. This study included a total of 144 patients with severe hemophilia A. Of them, 66 had acute joint bleeding. Ninety healthy volunteers were recruited as control. The levels of leukocytes, monocytes, platelets, hemoglobin, phagocyte migration inhibitory factor (MIF), plasminogen, fibrin/fibrinogen degradation products, d -dimer, and α2 antifibrinolytic enzyme were measured using hematology analyzer. Thrombomodulin, endostatin, intercellular adhesion molecule 1, and vascular endothelial growth factor (VEGF) were assessed using enzyme-linked immunosorbent assay. Logistic regression analysis was performed to analyze the factors affecting acute joint bleeding. Compared with healthy volunteers, the levels of leukocytes, C-reactive protein (CRP), MIF, and VEGF were significantly ( P < .05) elevated in the patients with severe hemophilia A and were significantly higher in patients with joint bleeding than in patients with nonbleeding ( P < .05). Multivariate analysis showed that CRP and VEGF were independent risk factors for acute joint bleeding ( P < .05). The area under the curve, sensitivity, and specificity of CRP for the diagnosis of acute joint bleeding were 0.829, 88.43%, and 67.87%, respectively, and those of VEGF were 0.758, 82.8%, and 68.3%, respectively. The levels of inflammatory factors and angiogenesis factors are elevated in patients with severe hemophilia A and both CRP and VEGF are closely related to acute joint bleeding and may be used as potential biomarkers for predicting acute joint bleeding in patients with severe hemophilia A.https://doi.org/10.1177/1076029619892683 |
| spellingShingle | Huijuan Xu PhD Ren Zhong PhD Kai Wang PhD Xuerong Li PhD Yanxia Zhao PhD Jian Jiang PhD Shaoyong Si PhD Lirong Sun PhD Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A Clinical and Applied Thrombosis/Hemostasis |
| title | Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A |
| title_full | Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A |
| title_fullStr | Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A |
| title_full_unstemmed | Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A |
| title_short | Diagnostic Values of Inflammatory and Angiogenic Factors for Acute Joint Bleeding in Patients With Severe Hemophilia A |
| title_sort | diagnostic values of inflammatory and angiogenic factors for acute joint bleeding in patients with severe hemophilia a |
| url | https://doi.org/10.1177/1076029619892683 |
| work_keys_str_mv | AT huijuanxuphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT renzhongphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT kaiwangphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT xuerongliphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT yanxiazhaophd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT jianjiangphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT shaoyongsiphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa AT lirongsunphd diagnosticvaluesofinflammatoryandangiogenicfactorsforacutejointbleedinginpatientswithseverehemophiliaa |