Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

Summary: The brain of Down syndrome (DS) patients exhibits fewer interneurons in the cerebral cortex, but its underlying mechanism remains unknown. By morphometric analysis of cortical interneurons generated from DS and euploid induced pluripotent stem cells (iPSCs), we found that DS GABA neurons ar...

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Bibliografski detalji
Glavni autori: Hai-Qin Huo, Zhuang-Yin Qu, Fang Yuan, Lixiang Ma, Lin Yao, Min Xu, Yao Hu, Jing Ji, Anita Bhattacharyya, Su-Chun Zhang, Yan Liu
Format: Članak
Jezik:English
Izdano: Elsevier 2018-04-01
Serija:Stem Cell Reports
Online pristup:http://www.sciencedirect.com/science/article/pii/S2213671118300699

Internet

http://www.sciencedirect.com/science/article/pii/S2213671118300699

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