Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review
Background: Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-11-01
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| Series: | Journal of Applied Biomaterials & Functional Materials |
| Online Access: | https://doi.org/10.1177/22808000231211416 |
| _version_ | 1827728438277963776 |
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| author | Florencia Antunovic Felipe Tolosa Catherine Klein René Ocaranza |
| author_facet | Florencia Antunovic Felipe Tolosa Catherine Klein René Ocaranza |
| author_sort | Florencia Antunovic |
| collection | DOAJ |
| description | Background: Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process. Methods: This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates. Results: Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide. Conclusions: PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential. |
| first_indexed | 2024-03-10T23:29:09Z |
| format | Article |
| id | doaj.art-e0f0998f8f1a4e65b36f85b8e6792db6 |
| institution | Directory Open Access Journal |
| issn | 2280-8000 |
| language | English |
| last_indexed | 2024-03-10T23:29:09Z |
| publishDate | 2023-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Applied Biomaterials & Functional Materials |
| spelling | doaj.art-e0f0998f8f1a4e65b36f85b8e6792db62023-11-19T07:33:41ZengSAGE PublishingJournal of Applied Biomaterials & Functional Materials2280-80002023-11-012110.1177/22808000231211416Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic reviewFlorencia Antunovic0Felipe Tolosa1Catherine Klein2René Ocaranza3Escuela de Odontología, Facultad de Medicina – Clínica Alemana de Santiago Universidad del Desarrollo, Santiago de Chile, ChileEscuela de Odontología, Facultad de Medicina – Clínica Alemana de Santiago Universidad del Desarrollo, Santiago de Chile, ChileEspecialidad de Periodoncia, Escuela de Odontología, Facultad de Medicina – Clínica Alemana de Santiago Universidad del Desarrollo, Santiago de Chile, ChileEspecialidad de Periodoncia, Escuela de Odontología, Facultad de Medicina – Clínica Alemana de Santiago Universidad del Desarrollo, Santiago de Chile, ChileBackground: Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process. Methods: This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates. Results: Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide. Conclusions: PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential.https://doi.org/10.1177/22808000231211416 |
| spellingShingle | Florencia Antunovic Felipe Tolosa Catherine Klein René Ocaranza Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review Journal of Applied Biomaterials & Functional Materials |
| title | Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review |
| title_full | Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review |
| title_fullStr | Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review |
| title_full_unstemmed | Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review |
| title_short | Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review |
| title_sort | polycaprolactone based scaffolds for guided tissue regeneration in periodontal therapy a systematic review |
| url | https://doi.org/10.1177/22808000231211416 |
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