Association between glucosamine use and cancer mortality: A large prospective cohort study
ObjectivePrevious studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers based on the UK Biobank cohort study.Materials and methodsA tot...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.947818/full |
| _version_ | 1811326428565733376 |
|---|---|
| author | Jian Zhou Ziyi Wu Zhengjun Lin Wanchun Wang Rongjun Wan Rongjun Wan Tang Liu |
| author_facet | Jian Zhou Ziyi Wu Zhengjun Lin Wanchun Wang Rongjun Wan Rongjun Wan Tang Liu |
| author_sort | Jian Zhou |
| collection | DOAJ |
| description | ObjectivePrevious studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers based on the UK Biobank cohort study.Materials and methodsA total of 453,645 participants aged 38–73 who had no cancer at baseline were recruited between 2006 and 2010 and followed until March 2021. We used cox and poission proportional hazards models to explore the association between habitual use of glucosamine and cancer mortality. Subgroup analyses were conducted to understand the potential effect modifications of demographics, lifestyle factors, and health outcomes. Sensitivity analyses were performed to determine the robustness of the results.ResultsOf the participants, 88,224 (19.4%) reported habitual glucosamine use at baseline. There were 9,366 cancer deaths during a median follow-up of 12.1 years, and we observed a significant association between the use of glucosamine and lower overall cancer mortality (HR = 0.95, 95% CI = 0.90–1.00, p < 0.05), kidney cancer (IRR = 0.68, 95% CI = 0.49–0.95, p < 0.05), lung cancer mortality (IRR = 0.84, 95% CI = 0.74–0.95, p < 0.05), and rectum cancer (IRR = 0.76, 95% CI = 0.59–0.98, p < 0.05). Subgroup analysis showed that habitual glucosamine supplementation was correlated with lower overall cancer mortality among participants who were aged ≥ 60 years, male, current smoker, without high cholesterol and not obese. Sensitivity analysis showed that the results were stable.ConclusionHabitual glucosamine use was significantly related to decreased overall cancer, kidney cancer, lung cancer, and rectum cancer mortality, based on data from the large-scale, nationwide, prospective UK Biobank cohort study. |
| first_indexed | 2024-04-13T14:49:12Z |
| format | Article |
| id | doaj.art-e0f0e72146e34eb6bf4e1617a237f557 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-13T14:49:12Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-e0f0e72146e34eb6bf4e1617a237f5572022-12-22T02:42:39ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-11-01910.3389/fnut.2022.947818947818Association between glucosamine use and cancer mortality: A large prospective cohort studyJian Zhou0Ziyi Wu1Zhengjun Lin2Wanchun Wang3Rongjun Wan4Rongjun Wan5Tang Liu6Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaLaboratory of Bone Disorder, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaDepartment of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, ChinaObjectivePrevious studies have shown anti-cancer and anti-inflammatory benefits of glucosamine. This study was performed to prospectively evaluate the association between glucosamine supplementation and the mortality of multiple cancers based on the UK Biobank cohort study.Materials and methodsA total of 453,645 participants aged 38–73 who had no cancer at baseline were recruited between 2006 and 2010 and followed until March 2021. We used cox and poission proportional hazards models to explore the association between habitual use of glucosamine and cancer mortality. Subgroup analyses were conducted to understand the potential effect modifications of demographics, lifestyle factors, and health outcomes. Sensitivity analyses were performed to determine the robustness of the results.ResultsOf the participants, 88,224 (19.4%) reported habitual glucosamine use at baseline. There were 9,366 cancer deaths during a median follow-up of 12.1 years, and we observed a significant association between the use of glucosamine and lower overall cancer mortality (HR = 0.95, 95% CI = 0.90–1.00, p < 0.05), kidney cancer (IRR = 0.68, 95% CI = 0.49–0.95, p < 0.05), lung cancer mortality (IRR = 0.84, 95% CI = 0.74–0.95, p < 0.05), and rectum cancer (IRR = 0.76, 95% CI = 0.59–0.98, p < 0.05). Subgroup analysis showed that habitual glucosamine supplementation was correlated with lower overall cancer mortality among participants who were aged ≥ 60 years, male, current smoker, without high cholesterol and not obese. Sensitivity analysis showed that the results were stable.ConclusionHabitual glucosamine use was significantly related to decreased overall cancer, kidney cancer, lung cancer, and rectum cancer mortality, based on data from the large-scale, nationwide, prospective UK Biobank cohort study.https://www.frontiersin.org/articles/10.3389/fnut.2022.947818/fullglucosaminecancercohort studymortalityUK Biobank |
| spellingShingle | Jian Zhou Ziyi Wu Zhengjun Lin Wanchun Wang Rongjun Wan Rongjun Wan Tang Liu Association between glucosamine use and cancer mortality: A large prospective cohort study Frontiers in Nutrition glucosamine cancer cohort study mortality UK Biobank |
| title | Association between glucosamine use and cancer mortality: A large prospective cohort study |
| title_full | Association between glucosamine use and cancer mortality: A large prospective cohort study |
| title_fullStr | Association between glucosamine use and cancer mortality: A large prospective cohort study |
| title_full_unstemmed | Association between glucosamine use and cancer mortality: A large prospective cohort study |
| title_short | Association between glucosamine use and cancer mortality: A large prospective cohort study |
| title_sort | association between glucosamine use and cancer mortality a large prospective cohort study |
| topic | glucosamine cancer cohort study mortality UK Biobank |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.947818/full |
| work_keys_str_mv | AT jianzhou associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy AT ziyiwu associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy AT zhengjunlin associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy AT wanchunwang associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy AT rongjunwan associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy AT rongjunwan associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy AT tangliu associationbetweenglucosamineuseandcancermortalityalargeprospectivecohortstudy |