Atypical stress femoral shaft fracture secondary to alendronate therapy
Bisphosphonate (BP) therapy is widely used as it remains the first-line of treatment for osteoporosis. These antiresorptive drugs inhibit osteoclast function and promote apoptosis. However, atypical stress femoral fractures occurring in the diaphysis and subtrochanteric region are linked to prolonge...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Orthopedics, Traumatology and Rehabilitation |
| Subjects: | |
| Online Access: | http://www.jotr.in/article.asp?issn=0975-7341;year=2020;volume=12;issue=1;spage=92;epage=94;aulast=Ardebol |
| _version_ | 1819204332115984384 |
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| author | Javier Ardebol Mario Cahueque Viriato Mere Jose Domingo Soto |
| author_facet | Javier Ardebol Mario Cahueque Viriato Mere Jose Domingo Soto |
| author_sort | Javier Ardebol |
| collection | DOAJ |
| description | Bisphosphonate (BP) therapy is widely used as it remains the first-line of treatment for osteoporosis. These antiresorptive drugs inhibit osteoclast function and promote apoptosis. However, atypical stress femoral fractures occurring in the diaphysis and subtrochanteric region are linked to prolonged BP use. The risk of fracture is directly proportional to the time exposed to the treatment. Ongoing BP exposure prevents bone resorption and replacement in areas with accumulated microdamage through targeted remodeling. Therefore, long-term BP use (more than 5 years) is an important risk factor. Atypical femoral fractures remain very rare, and the benefits of BP therapy for osteoporotic fracture prevention and treatment outweigh the risk. The present report consists of a rare case of a patient with an atypical diaphyseal femoral stress fracture secondary to prolonged alendronate use. |
| first_indexed | 2024-12-23T04:34:07Z |
| format | Article |
| id | doaj.art-e0f42cae892a4f1fa0380663f10fb972 |
| institution | Directory Open Access Journal |
| issn | 0975-7341 |
| language | English |
| last_indexed | 2024-12-23T04:34:07Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orthopedics, Traumatology and Rehabilitation |
| spelling | doaj.art-e0f42cae892a4f1fa0380663f10fb9722022-12-21T17:59:56ZengWolters Kluwer Medknow PublicationsJournal of Orthopedics, Traumatology and Rehabilitation0975-73412020-01-01121929410.4103/jotr.jotr_11_20Atypical stress femoral shaft fracture secondary to alendronate therapyJavier ArdebolMario CahuequeViriato MereJose Domingo SotoBisphosphonate (BP) therapy is widely used as it remains the first-line of treatment for osteoporosis. These antiresorptive drugs inhibit osteoclast function and promote apoptosis. However, atypical stress femoral fractures occurring in the diaphysis and subtrochanteric region are linked to prolonged BP use. The risk of fracture is directly proportional to the time exposed to the treatment. Ongoing BP exposure prevents bone resorption and replacement in areas with accumulated microdamage through targeted remodeling. Therefore, long-term BP use (more than 5 years) is an important risk factor. Atypical femoral fractures remain very rare, and the benefits of BP therapy for osteoporotic fracture prevention and treatment outweigh the risk. The present report consists of a rare case of a patient with an atypical diaphyseal femoral stress fracture secondary to prolonged alendronate use.http://www.jotr.in/article.asp?issn=0975-7341;year=2020;volume=12;issue=1;spage=92;epage=94;aulast=Ardebolatypical fracturebisphosphonateconservativesub-trochanteric region |
| spellingShingle | Javier Ardebol Mario Cahueque Viriato Mere Jose Domingo Soto Atypical stress femoral shaft fracture secondary to alendronate therapy Journal of Orthopedics, Traumatology and Rehabilitation atypical fracture bisphosphonate conservative sub-trochanteric region |
| title | Atypical stress femoral shaft fracture secondary to alendronate therapy |
| title_full | Atypical stress femoral shaft fracture secondary to alendronate therapy |
| title_fullStr | Atypical stress femoral shaft fracture secondary to alendronate therapy |
| title_full_unstemmed | Atypical stress femoral shaft fracture secondary to alendronate therapy |
| title_short | Atypical stress femoral shaft fracture secondary to alendronate therapy |
| title_sort | atypical stress femoral shaft fracture secondary to alendronate therapy |
| topic | atypical fracture bisphosphonate conservative sub-trochanteric region |
| url | http://www.jotr.in/article.asp?issn=0975-7341;year=2020;volume=12;issue=1;spage=92;epage=94;aulast=Ardebol |
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