Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India
Background Autistic Spectrum Disorder (ASD) is a neurodevelopmental disorder. There is a large quantity of evidence which point towards a positive correlation between Autism and Mitochondrial disorders (MD). In addition to that, several published reports, indicate that people with neurological diso...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-06-01
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| Series: | International Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://ijp.mums.ac.ir/article_6893_01e16bf86c6a6c21c5b872e665e477ea.pdf |
| _version_ | 1798024238852997120 |
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| author | Rashmi Chowdhary Roji Khan Girish Bhatt Yash Malik Rajesh Malik Sudhir Goel |
| author_facet | Rashmi Chowdhary Roji Khan Girish Bhatt Yash Malik Rajesh Malik Sudhir Goel |
| author_sort | Rashmi Chowdhary |
| collection | DOAJ |
| description | Background Autistic Spectrum Disorder (ASD) is a neurodevelopmental disorder. There is a large quantity of evidence which point towards a positive correlation between Autism and Mitochondrial disorders (MD). In addition to that, several published reports, indicate that people with neurological disorders exhibit pathological signs of mitochondrial disorders and vice versa. Screening for underlying MD is essential in ASD as the children (clinically) appear and behave the same way in the both instances; however, their management is very different. Materials and Methods The current study examined biochemical, neuroimaging and genotyping technique in ASD patients to see which technique would be easier to interpret and indicate underlying MD. The analysis of the screening was based on several objectives like clinical, histological, biochemical, molecular, neuroimaging and enzymatic findings. Results We found out that pathogenetic analysis based on clinical and genotyping gives spontaneous results to analyse the possibility of MD in ASD patients. Conclusion It does not necessarily require blood samples from ASD patients to accomplish this type of analysis. |
| first_indexed | 2024-04-11T17:59:11Z |
| format | Article |
| id | doaj.art-e0f804755c4f4debb1871e4f76c7e149 |
| institution | Directory Open Access Journal |
| issn | 2345-5047 2345-5055 |
| language | English |
| last_indexed | 2024-04-11T17:59:11Z |
| publishDate | 2016-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj.art-e0f804755c4f4debb1871e4f76c7e1492022-12-22T04:10:35ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552016-06-0146187718836893Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of IndiaRashmi Chowdhary0Roji Khan1Girish Bhatt2Yash Malik3Rajesh Malik4Sudhir Goel5Assistant Professor Biochemistry AIIMS Bhopal, India.Junior Research Fellow, Department of Biochemistry, AIIMS Bhopal, India.Assistant Professor, Department of Pediatrics, AIIMS Bhopal, India.MBBS Student, AIIMS Bhopal, India.Professor, Head, Department of Radiodiagnosis, AIIMS Bhopal, India.Professor, Head, Department of Biochemistry, AIIMS Bhopal, India.Background Autistic Spectrum Disorder (ASD) is a neurodevelopmental disorder. There is a large quantity of evidence which point towards a positive correlation between Autism and Mitochondrial disorders (MD). In addition to that, several published reports, indicate that people with neurological disorders exhibit pathological signs of mitochondrial disorders and vice versa. Screening for underlying MD is essential in ASD as the children (clinically) appear and behave the same way in the both instances; however, their management is very different. Materials and Methods The current study examined biochemical, neuroimaging and genotyping technique in ASD patients to see which technique would be easier to interpret and indicate underlying MD. The analysis of the screening was based on several objectives like clinical, histological, biochemical, molecular, neuroimaging and enzymatic findings. Results We found out that pathogenetic analysis based on clinical and genotyping gives spontaneous results to analyse the possibility of MD in ASD patients. Conclusion It does not necessarily require blood samples from ASD patients to accomplish this type of analysis.http://ijp.mums.ac.ir/article_6893_01e16bf86c6a6c21c5b872e665e477ea.pdfAutistic Spectrum DisorderChildrenMitochondrial DNA |
| spellingShingle | Rashmi Chowdhary Roji Khan Girish Bhatt Yash Malik Rajesh Malik Sudhir Goel Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India International Journal of Pediatrics Autistic Spectrum Disorder Children Mitochondrial DNA |
| title | Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India |
| title_full | Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India |
| title_fullStr | Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India |
| title_full_unstemmed | Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India |
| title_short | Projection of Need for Pathogenetic Testing for Mitochondrial Dysfunction in Autistic Spectrum Disorder (ASD) Children of India |
| title_sort | projection of need for pathogenetic testing for mitochondrial dysfunction in autistic spectrum disorder asd children of india |
| topic | Autistic Spectrum Disorder Children Mitochondrial DNA |
| url | http://ijp.mums.ac.ir/article_6893_01e16bf86c6a6c21c5b872e665e477ea.pdf |
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