Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer
Zearalenone (ZEN) is a Fusarium-derived mycotoxin, exerting xenoestrogenic effects in animals and humans. ZEN and its derivatives commonly occur in cereals and cereal-based products. During the biotransformation of ZEN, its reduced metabolites, α-zearalenol (α-ZEL) and β...
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| Format: | Article |
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MDPI AG
2018-05-01
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| Series: | Toxins |
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| Online Access: | http://www.mdpi.com/2072-6651/10/6/216 |
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| author | Miklós Poór Zelma Faisal Afshin Zand Tímea Bencsik Beáta Lemli Sándor Kunsági-Máté Lajos Szente |
| author_facet | Miklós Poór Zelma Faisal Afshin Zand Tímea Bencsik Beáta Lemli Sándor Kunsági-Máté Lajos Szente |
| author_sort | Miklós Poór |
| collection | DOAJ |
| description | Zearalenone (ZEN) is a Fusarium-derived mycotoxin, exerting xenoestrogenic effects in animals and humans. ZEN and its derivatives commonly occur in cereals and cereal-based products. During the biotransformation of ZEN, its reduced metabolites, α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL), are formed; α-ZEL is even more toxic than the parent compound ZEN. Since previous studies demonstrated that ZEN and ZELs form stable complexes with β-cyclodextrins, it is reasonable to hypothesize that cyclodextrin polymers may be suitable for mycotoxin removal from aqueous solutions. In this study, the extraction of ZEN and ZELs from water, buffers, and corn beer was investigated, employing insoluble β-cyclodextrin bead polymer (BBP) as a mycotoxin-binder. Our results demonstrate that even relatively small amounts of BBP can strongly decrease the mycotoxin content of aqueous solutions (including beer). After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture. Therefore, our study suggests that insoluble cyclodextrin polymers may be suitable tools in the future to deplete mycotoxins from contaminated drinks. |
| first_indexed | 2024-04-14T03:35:06Z |
| format | Article |
| id | doaj.art-e0f92f97168647098fb1b59f56ced691 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-14T03:35:06Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-e0f92f97168647098fb1b59f56ced6912022-12-22T02:14:48ZengMDPI AGToxins2072-66512018-05-0110621610.3390/toxins10060216toxins10060216Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead PolymerMiklós Poór0Zelma Faisal1Afshin Zand2Tímea Bencsik3Beáta Lemli4Sándor Kunsági-Máté5Lajos Szente6Department of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, H-7624 Pécs, HungaryDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, H-7624 Pécs, HungaryDepartment of Pharmacology, Faculty of Pharmacy, University of Pécs, Szigeti út 12, H-7624 Pécs, HungaryInstitute of Pharmacognosy, University of Pécs, Faculty of Pharmacy, Rókus utca 2, H-7624 Pécs, HungaryJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624 Pécs, HungaryJános Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624 Pécs, HungaryCycloLab Cyclodextrin Research & Development Laboratory, Ltd., Illatos út 7, H-1097 Budapest, HungaryZearalenone (ZEN) is a Fusarium-derived mycotoxin, exerting xenoestrogenic effects in animals and humans. ZEN and its derivatives commonly occur in cereals and cereal-based products. During the biotransformation of ZEN, its reduced metabolites, α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL), are formed; α-ZEL is even more toxic than the parent compound ZEN. Since previous studies demonstrated that ZEN and ZELs form stable complexes with β-cyclodextrins, it is reasonable to hypothesize that cyclodextrin polymers may be suitable for mycotoxin removal from aqueous solutions. In this study, the extraction of ZEN and ZELs from water, buffers, and corn beer was investigated, employing insoluble β-cyclodextrin bead polymer (BBP) as a mycotoxin-binder. Our results demonstrate that even relatively small amounts of BBP can strongly decrease the mycotoxin content of aqueous solutions (including beer). After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture. Therefore, our study suggests that insoluble cyclodextrin polymers may be suitable tools in the future to deplete mycotoxins from contaminated drinks.http://www.mdpi.com/2072-6651/10/6/216zearalenonezearalenolsbeta-cyclodextrin bead polymertoxin removalbeer |
| spellingShingle | Miklós Poór Zelma Faisal Afshin Zand Tímea Bencsik Beáta Lemli Sándor Kunsági-Máté Lajos Szente Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer Toxins zearalenone zearalenols beta-cyclodextrin bead polymer toxin removal beer |
| title | Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer |
| title_full | Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer |
| title_fullStr | Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer |
| title_full_unstemmed | Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer |
| title_short | Removal of Zearalenone and Zearalenols from Aqueous Solutions Using Insoluble Beta-Cyclodextrin Bead Polymer |
| title_sort | removal of zearalenone and zearalenols from aqueous solutions using insoluble beta cyclodextrin bead polymer |
| topic | zearalenone zearalenols beta-cyclodextrin bead polymer toxin removal beer |
| url | http://www.mdpi.com/2072-6651/10/6/216 |
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