Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative

Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative

Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms. Excessive or inappropriate TLR4 activation causes the development of many autoimmune diseases. Dihydropyrimidinone derivatives are medicin...

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Bibliographic Details
Main Authors: Mingqian Zhou, Yiqi Wang, Xiaoying Lin, Jieping Wan, Chengping Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
3
4-dihydropyrimidinones
DHPMs
TLR4
antagonist
inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.624059/full

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