From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders

From tryptamine to the discovery of efficient multi-target directed ligands against cholinesterase-associated neurodegenerative disorders

A novel class of benzyl-free and benzyl-substituted carbamylated tryptamine derivatives (CDTs) was designed and synthesized to serve as effective building blocks for the development of novel multi-target directed ligands (MTDLs) for the treatment of neurological disorders linked to cholinesterase (C...

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Bibliographic Details
Main Authors:	Junbo Wu, Honghua Zhang, Yuying Wang, Gaofeng Yin, Qien Li, Linsheng Zhuo, Hongjin Chen, Zhen Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Pharmacology
Subjects:	carbamylated tryptamine derivatives benzylation promising building blocks MTDLs cholinesterase inhibitors neuroprotection
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1036030/full

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