Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study
There have been conflicting results regarding the association between diabetes and the risk of hematologic malignancies, and its interaction with obesity is unknown. This study determined the risk of hematologic malignancies according to the glycemic status in a population-based study involving heal...
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MDPI AG
2021-09-01
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4760 |
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| author | Jihun Kang Sang-Man Jin Seok Jin Kim Dahye Kim Kyungdo Han Su-Min Jeong JiWon Chang Sang Youl Rhee Taewoong Choi Dong Wook Shin |
| author_facet | Jihun Kang Sang-Man Jin Seok Jin Kim Dahye Kim Kyungdo Han Su-Min Jeong JiWon Chang Sang Youl Rhee Taewoong Choi Dong Wook Shin |
| author_sort | Jihun Kang |
| collection | DOAJ |
| description | There have been conflicting results regarding the association between diabetes and the risk of hematologic malignancies, and its interaction with obesity is unknown. This study determined the risk of hematologic malignancies according to the glycemic status in a population-based study involving health screening 9,774,625 participants. The baseline glycemic status of the participants was categorized into no diabetes, impaired fasting glucose (IFG), newly detected diabetes, diabetes duration <5 years, and diabetes duration ≥5 year groups. The risks of overall and specific hematologic malignancies were estimated using a Cox regression analysis. During a median follow up of 7.3 years, 14,733 hematologic malignancies developed. The adjusted hazard ratio (aHR) for the risk of all the hematologic malignancies was 0.99 (95% confidence interval (CI) 0.95–1.02) for IFG, 0.99 (95% CI 0.91–1.08) for newly detected diabetes, 1.03 (95% CI 0.96–1.11) for diabetes duration <5 years, and 1.11 (95% CI 1.03, 1.20) for diabetes duration ≥5 year groups. The association was independent from obesity. The risk of non-Hodgkin’s lymphoma (NHL) increased according to the progression of dysglycemia towards a longer diabetes duration, while Hodgkin’s lymphoma did not. This study in Korea demonstrated diabetes to be associated with an increased risk of hematologic malignancies independent of obesity. The NHL risk increased with the diabetes duration. |
| first_indexed | 2024-03-10T07:06:10Z |
| format | Article |
| id | doaj.art-e0f9d06ffc1d41ef9e4b323b6fe134b3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:06:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e0f9d06ffc1d41ef9e4b323b6fe134b32023-11-22T15:51:56ZengMDPI AGCancers2072-66942021-09-011319476010.3390/cancers13194760Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort StudyJihun Kang0Sang-Man Jin1Seok Jin Kim2Dahye Kim3Kyungdo Han4Su-Min Jeong5JiWon Chang6Sang Youl Rhee7Taewoong Choi8Dong Wook Shin9Department of Family Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan 49267, KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDivision of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Medical Statistics, The Catholic University of Korea, Seoul 03083, KoreaDepartment of Statistics and Actuarial Science, Soongsil University, Seoul 06978, KoreaDepartment of Family Medicine, Boramae Medical Center, Seoul Metropolitan Government-Seoul National University, Seoul 07061, KoreaSupportive Care Center, Samsung Medical Center, Seoul 06351, KoreaDepartment of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul 02453, KoreaDivision of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USASupportive Care Center, Samsung Medical Center, Seoul 06351, KoreaThere have been conflicting results regarding the association between diabetes and the risk of hematologic malignancies, and its interaction with obesity is unknown. This study determined the risk of hematologic malignancies according to the glycemic status in a population-based study involving health screening 9,774,625 participants. The baseline glycemic status of the participants was categorized into no diabetes, impaired fasting glucose (IFG), newly detected diabetes, diabetes duration <5 years, and diabetes duration ≥5 year groups. The risks of overall and specific hematologic malignancies were estimated using a Cox regression analysis. During a median follow up of 7.3 years, 14,733 hematologic malignancies developed. The adjusted hazard ratio (aHR) for the risk of all the hematologic malignancies was 0.99 (95% confidence interval (CI) 0.95–1.02) for IFG, 0.99 (95% CI 0.91–1.08) for newly detected diabetes, 1.03 (95% CI 0.96–1.11) for diabetes duration <5 years, and 1.11 (95% CI 1.03, 1.20) for diabetes duration ≥5 year groups. The association was independent from obesity. The risk of non-Hodgkin’s lymphoma (NHL) increased according to the progression of dysglycemia towards a longer diabetes duration, while Hodgkin’s lymphoma did not. This study in Korea demonstrated diabetes to be associated with an increased risk of hematologic malignancies independent of obesity. The NHL risk increased with the diabetes duration.https://www.mdpi.com/2072-6694/13/19/4760hematologic malignanciesHodgkin’s lymphomanon-Hodgkin’s lymphomadiabetesglycemic status |
| spellingShingle | Jihun Kang Sang-Man Jin Seok Jin Kim Dahye Kim Kyungdo Han Su-Min Jeong JiWon Chang Sang Youl Rhee Taewoong Choi Dong Wook Shin Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study Cancers hematologic malignancies Hodgkin’s lymphoma non-Hodgkin’s lymphoma diabetes glycemic status |
| title | Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study |
| title_full | Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study |
| title_fullStr | Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study |
| title_full_unstemmed | Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study |
| title_short | Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study |
| title_sort | obesity independent association between glycemic status and the risk of hematologic malignancy a nationwide population based longitudinal cohort study |
| topic | hematologic malignancies Hodgkin’s lymphoma non-Hodgkin’s lymphoma diabetes glycemic status |
| url | https://www.mdpi.com/2072-6694/13/19/4760 |
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