Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study
Abstract To investigate the relationship between serum high-density lipoprotein (HDL-C) and spinal bone mineral density (BMD) under different serum 25-hydroxyvitamin D (25 (OH) D) levels in adults over 40 years old and to explore its mechanism. We include participants over the age of 40 with data on...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-022-03491-w |
| _version_ | 1797958606122909696 |
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| author | Peng Gu Bin Pu BaiHang Chen XiaoHui Zheng ZhanPeng Zeng WeiDong Luo |
| author_facet | Peng Gu Bin Pu BaiHang Chen XiaoHui Zheng ZhanPeng Zeng WeiDong Luo |
| author_sort | Peng Gu |
| collection | DOAJ |
| description | Abstract To investigate the relationship between serum high-density lipoprotein (HDL-C) and spinal bone mineral density (BMD) under different serum 25-hydroxyvitamin D (25 (OH) D) levels in adults over 40 years old and to explore its mechanism. We include participants over the age of 40 with data on HDL-C, 25 (OH) D, spinal BMD, and other variables in the National Health and Nutrition Examination Survey 2007–2010 in the analysis. A weighted multiple linear regression model was used to evaluate the association between serum HDL-C and spinal BMD in different gender, ages, and serum 25 (OH) D levels. A total of 3599 subjects aged ≥ 40 years old were included in this study. Univariate analysis of the complete correction model showed a negative correlation between serum HDL-C and spinal BMD. In the two subgroups of serum 25 (OH) D, we found that the higher the serum HDL-C in the female with serum 25 (OH) D < 75 nmol/L aged 40–59 years old, the lower the total spinal BMD, and a similar relationship was found in the lumbar spine. However, no similar relationship was found in all populations with serum 25 (OH) D ≥ 75 nmol/L and males with serum 25 (OH) D < 75 nmol/L. These results suggest that among Americans over the age of 40, the increase in serum HDL-C is related to decreased BMD of spine only in women aged 40–59 years with vitamin D insufficiency or deficiency. |
| first_indexed | 2024-04-11T00:21:16Z |
| format | Article |
| id | doaj.art-e0fb732fb7a94ed49165d062251c52ab |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T00:21:16Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-e0fb732fb7a94ed49165d062251c52ab2023-01-08T12:16:42ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-01-0118111010.1186/s13018-022-03491-wEffects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional studyPeng Gu0Bin Pu1BaiHang Chen2XiaoHui Zheng3ZhanPeng Zeng4WeiDong Luo5Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineAbstract To investigate the relationship between serum high-density lipoprotein (HDL-C) and spinal bone mineral density (BMD) under different serum 25-hydroxyvitamin D (25 (OH) D) levels in adults over 40 years old and to explore its mechanism. We include participants over the age of 40 with data on HDL-C, 25 (OH) D, spinal BMD, and other variables in the National Health and Nutrition Examination Survey 2007–2010 in the analysis. A weighted multiple linear regression model was used to evaluate the association between serum HDL-C and spinal BMD in different gender, ages, and serum 25 (OH) D levels. A total of 3599 subjects aged ≥ 40 years old were included in this study. Univariate analysis of the complete correction model showed a negative correlation between serum HDL-C and spinal BMD. In the two subgroups of serum 25 (OH) D, we found that the higher the serum HDL-C in the female with serum 25 (OH) D < 75 nmol/L aged 40–59 years old, the lower the total spinal BMD, and a similar relationship was found in the lumbar spine. However, no similar relationship was found in all populations with serum 25 (OH) D ≥ 75 nmol/L and males with serum 25 (OH) D < 75 nmol/L. These results suggest that among Americans over the age of 40, the increase in serum HDL-C is related to decreased BMD of spine only in women aged 40–59 years with vitamin D insufficiency or deficiency.https://doi.org/10.1186/s13018-022-03491-wBone mineral density25-Hydroxyvitamin DHigh-density lipoprotein cholesterolOsteoporosisNHANES |
| spellingShingle | Peng Gu Bin Pu BaiHang Chen XiaoHui Zheng ZhanPeng Zeng WeiDong Luo Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study Journal of Orthopaedic Surgery and Research Bone mineral density 25-Hydroxyvitamin D High-density lipoprotein cholesterol Osteoporosis NHANES |
| title | Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study |
| title_full | Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study |
| title_fullStr | Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study |
| title_full_unstemmed | Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study |
| title_short | Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study |
| title_sort | effects of vitamin d deficiency on blood lipids and bone metabolism a large cross sectional study |
| topic | Bone mineral density 25-Hydroxyvitamin D High-density lipoprotein cholesterol Osteoporosis NHANES |
| url | https://doi.org/10.1186/s13018-022-03491-w |
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