Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment
Objective It is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study aimed to characterize DAT changes in relation to nonmotor features in iRBD patients...
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| Format: | Article |
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Korean Movement Disorder Society
2019-05-01
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| Series: | Journal of Movement Disorders |
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| Online Access: | http://www.e-jmd.org/upload/jmd-18061.pdf |
| _version_ | 1797716081492623360 |
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| author | Jee-Young Lee Eun Jin Yoon Yu Kyeong Kim Chae Won Shin Hyunwoo Nam Jae Min Jeong Han-Joon Kim Beomseok Jeon |
| author_facet | Jee-Young Lee Eun Jin Yoon Yu Kyeong Kim Chae Won Shin Hyunwoo Nam Jae Min Jeong Han-Joon Kim Beomseok Jeon |
| author_sort | Jee-Young Lee |
| collection | DOAJ |
| description | Objective It is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study aimed to characterize DAT changes in relation to nonmotor features in iRBD patients by olfactory loss. Methods This prospective cohort study consisted of three age-matched groups: 30 polysomnography-confirmed iRBD patients, 30 drug-naïve Parkinson’s disease patients, and 19 healthy controls without olfactory impairment. The iRBD group was divided into two groups based on olfactory testing results. Participants were evaluated for reported prodromal markers and then underwent 18F-FP-CIT positron emission tomography and 3T MRI. Tracer uptakes were analyzed in the caudate, anterior and posterior putamen, substantia nigra, and raphe nuclei. Results Olfactory impairment was defined in 38.5% of iRBD patients. Mild parkinsonian signs and cognitive functions were not different between the two iRBD subgroups; however, additional prodromal features, constipation, and urinary and sexual dysfunctions were found in iRBD patients with olfactory impairment but not in those without. Tracer uptake showed significant group differences in all brain regions, except the raphe nuclei. The iRBD patients with olfactory impairment had uptake reductions in the anterior and posterior putamen, caudate, and substantia nigra (p < 0.016 in all, adjusted for age), which ranged from 0.6 to 0.8 of age-normative values. In contrast, those without olfactory impairment had insignificant changes in all regions ranging above 0.8. Conclusion There was a clear distinction in DAT loss and nonmotor profiles by olfactory status in iRBD. |
| first_indexed | 2024-03-12T08:16:14Z |
| format | Article |
| id | doaj.art-e0ff5616088d44a5bebcca20f5aee007 |
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| issn | 2005-940X 2093-4939 |
| language | English |
| last_indexed | 2024-03-12T08:16:14Z |
| publishDate | 2019-05-01 |
| publisher | Korean Movement Disorder Society |
| record_format | Article |
| series | Journal of Movement Disorders |
| spelling | doaj.art-e0ff5616088d44a5bebcca20f5aee0072023-09-02T18:53:33ZengKorean Movement Disorder SocietyJournal of Movement Disorders2005-940X2093-49392019-05-0112210311210.14802/jmd.18061250Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory ImpairmentJee-Young Lee0Eun Jin Yoon1Yu Kyeong Kim2Chae Won Shin3Hyunwoo Nam4Jae Min Jeong5Han-Joon Kim6Beomseok Jeon7 Department of Neurology, Seoul National University–Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea Department of Nuclear Medicine, Seoul National University–Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea Department of Nuclear Medicine, Seoul National University–Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea Department of Neurology, Kyung Hee University Medical Center, Seoul, Korea Department of Neurology, Seoul National University–Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul National University, Seoul, Korea Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Neurology, Seoul National University College of Medicine, Seoul, KoreaObjective It is unclear whether the decline in dopamine transporters (DAT) differs among idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with different levels of olfactory impairment. This study aimed to characterize DAT changes in relation to nonmotor features in iRBD patients by olfactory loss. Methods This prospective cohort study consisted of three age-matched groups: 30 polysomnography-confirmed iRBD patients, 30 drug-naïve Parkinson’s disease patients, and 19 healthy controls without olfactory impairment. The iRBD group was divided into two groups based on olfactory testing results. Participants were evaluated for reported prodromal markers and then underwent 18F-FP-CIT positron emission tomography and 3T MRI. Tracer uptakes were analyzed in the caudate, anterior and posterior putamen, substantia nigra, and raphe nuclei. Results Olfactory impairment was defined in 38.5% of iRBD patients. Mild parkinsonian signs and cognitive functions were not different between the two iRBD subgroups; however, additional prodromal features, constipation, and urinary and sexual dysfunctions were found in iRBD patients with olfactory impairment but not in those without. Tracer uptake showed significant group differences in all brain regions, except the raphe nuclei. The iRBD patients with olfactory impairment had uptake reductions in the anterior and posterior putamen, caudate, and substantia nigra (p < 0.016 in all, adjusted for age), which ranged from 0.6 to 0.8 of age-normative values. In contrast, those without olfactory impairment had insignificant changes in all regions ranging above 0.8. Conclusion There was a clear distinction in DAT loss and nonmotor profiles by olfactory status in iRBD.http://www.e-jmd.org/upload/jmd-18061.pdfIdiopathic REM sleep behavior disorderOlfactionParkinson’s diseaseDopamine transportersPositron emission tomography |
| spellingShingle | Jee-Young Lee Eun Jin Yoon Yu Kyeong Kim Chae Won Shin Hyunwoo Nam Jae Min Jeong Han-Joon Kim Beomseok Jeon Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment Journal of Movement Disorders Idiopathic REM sleep behavior disorder Olfaction Parkinson’s disease Dopamine transporters Positron emission tomography |
| title | Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment |
| title_full | Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment |
| title_fullStr | Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment |
| title_full_unstemmed | Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment |
| title_short | Nonmotor and Dopamine Transporter Change in REM Sleep Behavior Disorder by Olfactory Impairment |
| title_sort | nonmotor and dopamine transporter change in rem sleep behavior disorder by olfactory impairment |
| topic | Idiopathic REM sleep behavior disorder Olfaction Parkinson’s disease Dopamine transporters Positron emission tomography |
| url | http://www.e-jmd.org/upload/jmd-18061.pdf |
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