Molecular Mechanism of Cannabinoids in Cancer Progression
Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression;...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/7/3680 |
| _version_ | 1797539141818253312 |
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| author | Cristina Pagano Giovanna Navarra Laura Coppola Maurizio Bifulco Chiara Laezza |
| author_facet | Cristina Pagano Giovanna Navarra Laura Coppola Maurizio Bifulco Chiara Laezza |
| author_sort | Cristina Pagano |
| collection | DOAJ |
| description | Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis. |
| first_indexed | 2024-03-10T12:42:03Z |
| format | Article |
| id | doaj.art-e0ff8b8adafb4283ac63c35584ee3751 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:42:03Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e0ff8b8adafb4283ac63c35584ee37512023-11-21T13:52:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01227368010.3390/ijms22073680Molecular Mechanism of Cannabinoids in Cancer ProgressionCristina Pagano0Giovanna Navarra1Laura Coppola2Maurizio Bifulco3Chiara Laezza4Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyDepartment of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, ItalyInstitute of Endocrinology and Experimental Oncology, IEOS CNR, Via Pansini 5, 80131 Naples, ItalyCannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis.https://www.mdpi.com/1422-0067/22/7/3680cannabinoidscell deathmigrationangiogenesiscancer |
| spellingShingle | Cristina Pagano Giovanna Navarra Laura Coppola Maurizio Bifulco Chiara Laezza Molecular Mechanism of Cannabinoids in Cancer Progression International Journal of Molecular Sciences cannabinoids cell death migration angiogenesis cancer |
| title | Molecular Mechanism of Cannabinoids in Cancer Progression |
| title_full | Molecular Mechanism of Cannabinoids in Cancer Progression |
| title_fullStr | Molecular Mechanism of Cannabinoids in Cancer Progression |
| title_full_unstemmed | Molecular Mechanism of Cannabinoids in Cancer Progression |
| title_short | Molecular Mechanism of Cannabinoids in Cancer Progression |
| title_sort | molecular mechanism of cannabinoids in cancer progression |
| topic | cannabinoids cell death migration angiogenesis cancer |
| url | https://www.mdpi.com/1422-0067/22/7/3680 |
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