Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment
Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secr...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/10/1398 |
| _version_ | 1827680069049384960 |
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| author | Yanyu Huang Hsiao-Chi Wang Junwei Zhao Ming-Heng Wu Tsung-Chieh Shih |
| author_facet | Yanyu Huang Hsiao-Chi Wang Junwei Zhao Ming-Heng Wu Tsung-Chieh Shih |
| author_sort | Yanyu Huang |
| collection | DOAJ |
| description | Evasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1. |
| first_indexed | 2024-03-10T06:42:50Z |
| format | Article |
| id | doaj.art-e103963806ed43ed88a6e29b2b40922e |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T06:42:50Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-e103963806ed43ed88a6e29b2b40922e2023-11-22T17:32:55ZengMDPI AGBiomolecules2218-273X2021-09-011110139810.3390/biom11101398Immunosuppressive Roles of Galectin-1 in the Tumor MicroenvironmentYanyu Huang0Hsiao-Chi Wang1Junwei Zhao2Ming-Heng Wu3Tsung-Chieh Shih4Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USADepartment of Internal Medicine, University of California Davis, Sacramento, CA 95817, USADepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USAGraduate Institute of Translational Medicine and International Ph.D. Program for Translational Medicine, College of Medical Sciences and Technology, Taipei Medical University, Taipei 11031, TaiwanDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USAEvasion of immune surveillance is an accepted hallmark of tumor progression. The production of immune suppressive mediators by tumor cells is one of the major mechanisms of tumor immune escape. Galectin-1 (Gal-1), a pivotal immunosuppressive molecule, is expressed by many types of cancer. Tumor-secreted Gal-1 can bind to glycosylated receptors on immune cells and trigger the suppression of immune cell function in the tumor microenvironment, contributing to the immune evasion of tumors. The aim of this review is to summarize the current literature on the expression and function of Gal-1 in the human tumor microenvironment, as well as therapeutics targeting Gal-1.https://www.mdpi.com/2218-273X/11/10/1398Galectin-1immunotherapymicroenvironmentLLS30 |
| spellingShingle | Yanyu Huang Hsiao-Chi Wang Junwei Zhao Ming-Heng Wu Tsung-Chieh Shih Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment Biomolecules Galectin-1 immunotherapy microenvironment LLS30 |
| title | Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment |
| title_full | Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment |
| title_fullStr | Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment |
| title_full_unstemmed | Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment |
| title_short | Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment |
| title_sort | immunosuppressive roles of galectin 1 in the tumor microenvironment |
| topic | Galectin-1 immunotherapy microenvironment LLS30 |
| url | https://www.mdpi.com/2218-273X/11/10/1398 |
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