Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen supply. In vitro and in vivo experiments conducted...
Main Authors: | Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-12-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015267 |
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