Structures of the CcmABCD heme release complex at multiple states
Bacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a hypothetic model of heme trafficking, heme trans...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34136-5 |
| _version_ | 1811335151059206144 |
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| author | Jiao Li Wan Zheng Ming Gu Long Han Yanmei Luo Koukou Yu Mengxin Sun Yuliang Zong Xiuxiu Ma Bing Liu Ethan P. Lowder Deanna L. Mendez Robert G. Kranz Kai Zhang Jiapeng Zhu |
| author_facet | Jiao Li Wan Zheng Ming Gu Long Han Yanmei Luo Koukou Yu Mengxin Sun Yuliang Zong Xiuxiu Ma Bing Liu Ethan P. Lowder Deanna L. Mendez Robert G. Kranz Kai Zhang Jiapeng Zhu |
| author_sort | Jiao Li |
| collection | DOAJ |
| description | Bacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a hypothetic model of heme trafficking, heme transfer and release of holoCcmE. |
| first_indexed | 2024-04-13T17:19:53Z |
| format | Article |
| id | doaj.art-e104efcb27cf4836910eeadd14d685ba |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T17:19:53Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e104efcb27cf4836910eeadd14d685ba2022-12-22T02:38:02ZengNature PortfolioNature Communications2041-17232022-10-0113111310.1038/s41467-022-34136-5Structures of the CcmABCD heme release complex at multiple statesJiao Li0Wan Zheng1Ming Gu2Long Han3Yanmei Luo4Koukou Yu5Mengxin Sun6Yuliang Zong7Xiuxiu Ma8Bing Liu9Ethan P. Lowder10Deanna L. Mendez11Robert G. Kranz12Kai Zhang13Jiapeng Zhu14School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineDepartment of Molecular Biophysics and Biochemistry, Yale UniversitySchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineSchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineDepartment of Biology, Washington University in St. LouisDepartment of Biology, Washington University in St. LouisDepartment of Biology, Washington University in St. LouisDepartment of Molecular Biophysics and Biochemistry, Yale UniversitySchool of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese MedicineBacterial ABC transporter complex CcmABCD, a part of cytochrome c maturation system, transfers heme from one binding partner (CcmC) to another (CcmE). Here authors describe high resolution cryo-EM structures of CcmABCD in multiple states and propose a hypothetic model of heme trafficking, heme transfer and release of holoCcmE.https://doi.org/10.1038/s41467-022-34136-5 |
| spellingShingle | Jiao Li Wan Zheng Ming Gu Long Han Yanmei Luo Koukou Yu Mengxin Sun Yuliang Zong Xiuxiu Ma Bing Liu Ethan P. Lowder Deanna L. Mendez Robert G. Kranz Kai Zhang Jiapeng Zhu Structures of the CcmABCD heme release complex at multiple states Nature Communications |
| title | Structures of the CcmABCD heme release complex at multiple states |
| title_full | Structures of the CcmABCD heme release complex at multiple states |
| title_fullStr | Structures of the CcmABCD heme release complex at multiple states |
| title_full_unstemmed | Structures of the CcmABCD heme release complex at multiple states |
| title_short | Structures of the CcmABCD heme release complex at multiple states |
| title_sort | structures of the ccmabcd heme release complex at multiple states |
| url | https://doi.org/10.1038/s41467-022-34136-5 |
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