Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis
AbstractBackground Biomarkers of oxidative stress (OS) have been poorly explored in fungal peritonitis (FP). Potassium is a regulator of pro-oxidants and antioxidants. Albumin and vitamin B12 (B12) are vital antioxidant agents in the circulatory system. This study aimed to investigate the antioxidat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2021.1999489 |
| _version_ | 1797385733690884096 |
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| author | Lingling Liu Kehang Xie Mengmeng Yin Xiaoqiu Chen Binhuan Chen Jianting Ke Cheng Wang |
| author_facet | Lingling Liu Kehang Xie Mengmeng Yin Xiaoqiu Chen Binhuan Chen Jianting Ke Cheng Wang |
| author_sort | Lingling Liu |
| collection | DOAJ |
| description | AbstractBackground Biomarkers of oxidative stress (OS) have been poorly explored in fungal peritonitis (FP). Potassium is a regulator of pro-oxidants and antioxidants. Albumin and vitamin B12 (B12) are vital antioxidant agents in the circulatory system. This study aimed to investigate the antioxidative role of serum potassium, albumin and B12 in FP.Methods Serum levels of potassium, albumin and B12 were retrospectively analyzed in 21 patients with a confirmed diagnosis of FP, 105 bacterial peritonitis (BP) patients and 210 patients receiving peritoneal dialysis without peritonitis.Results Serum levels of potassium, albumin and B12 were lower in FP patients than in BP patients. Serum potassium concentration was statistically related to albumin concentration in peritonitis patients. Univariate and multivariate binary logistic regression analysis suggested that serum level of potassium and albumin were independent risk factors of FP when compared with BP. Lower potassium and B12 levels were independently associated with higher rates of technique failure in peritonitis.Conclusion These findings suggest lower serum potassium, albumin and B12 as potential oxidative stress markers of FP and raise the hypothesis that an increased level of OS could contribute to FP.KEY MESSAGESFP remains a serious complication of peritoneal dialysis (PD), with higher morbidity (1–23.8%) and mortality (2–25%), and oxidative stress plays a role in it.Our study suggested serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis. |
| first_indexed | 2024-03-08T21:58:31Z |
| format | Article |
| id | doaj.art-e10508162ada471f81a64960227e3ecd |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T21:58:31Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-e10508162ada471f81a64960227e3ecd2023-12-19T16:46:26ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602021-01-015312132214110.1080/07853890.2021.1999489Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitisLingling Liu0Kehang Xie1Mengmeng Yin2Xiaoqiu Chen3Binhuan Chen4Jianting Ke5Cheng Wang6Department of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Neurology, Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, Zhuhai, ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Nephrology, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaAbstractBackground Biomarkers of oxidative stress (OS) have been poorly explored in fungal peritonitis (FP). Potassium is a regulator of pro-oxidants and antioxidants. Albumin and vitamin B12 (B12) are vital antioxidant agents in the circulatory system. This study aimed to investigate the antioxidative role of serum potassium, albumin and B12 in FP.Methods Serum levels of potassium, albumin and B12 were retrospectively analyzed in 21 patients with a confirmed diagnosis of FP, 105 bacterial peritonitis (BP) patients and 210 patients receiving peritoneal dialysis without peritonitis.Results Serum levels of potassium, albumin and B12 were lower in FP patients than in BP patients. Serum potassium concentration was statistically related to albumin concentration in peritonitis patients. Univariate and multivariate binary logistic regression analysis suggested that serum level of potassium and albumin were independent risk factors of FP when compared with BP. Lower potassium and B12 levels were independently associated with higher rates of technique failure in peritonitis.Conclusion These findings suggest lower serum potassium, albumin and B12 as potential oxidative stress markers of FP and raise the hypothesis that an increased level of OS could contribute to FP.KEY MESSAGESFP remains a serious complication of peritoneal dialysis (PD), with higher morbidity (1–23.8%) and mortality (2–25%), and oxidative stress plays a role in it.Our study suggested serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis.https://www.tandfonline.com/doi/10.1080/07853890.2021.1999489Potassiumalbuminvitamin B12oxidative stressfungal peritonitis |
| spellingShingle | Lingling Liu Kehang Xie Mengmeng Yin Xiaoqiu Chen Binhuan Chen Jianting Ke Cheng Wang Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis Annals of Medicine Potassium albumin vitamin B12 oxidative stress fungal peritonitis |
| title | Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis |
| title_full | Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis |
| title_fullStr | Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis |
| title_full_unstemmed | Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis |
| title_short | Serum potassium, albumin and vitamin B12 as potential oxidative stress markers of fungal peritonitis |
| title_sort | serum potassium albumin and vitamin b12 as potential oxidative stress markers of fungal peritonitis |
| topic | Potassium albumin vitamin B12 oxidative stress fungal peritonitis |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2021.1999489 |
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