Oxidative Stress Response in <i>Pseudomonas aeruginosa</i>
<i>Pseudomonas aeruginosa</i> is a Gram-negative environmental and human opportunistic pathogen highly adapted to many different environmental conditions. It can cause a wide range of serious infections, including wounds, lungs, the urinary tract, and systemic infections. The high versat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/9/1187 |
| _version_ | 1797517692272377856 |
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| author | Waleska Stephanie da Cruz Nizer Vasily Inkovskiy Zoya Versey Nikola Strempel Edana Cassol Joerg Overhage |
| author_facet | Waleska Stephanie da Cruz Nizer Vasily Inkovskiy Zoya Versey Nikola Strempel Edana Cassol Joerg Overhage |
| author_sort | Waleska Stephanie da Cruz Nizer |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> is a Gram-negative environmental and human opportunistic pathogen highly adapted to many different environmental conditions. It can cause a wide range of serious infections, including wounds, lungs, the urinary tract, and systemic infections. The high versatility and pathogenicity of this bacterium is attributed to its genomic complexity, the expression of several virulence factors, and its intrinsic resistance to various antimicrobials. However, to thrive and establish infection, <i>P. aeruginosa</i> must overcome several barriers. One of these barriers is the presence of oxidizing agents (e.g., hydrogen peroxide, superoxide, and hypochlorous acid) produced by the host immune system or that are commonly used as disinfectants in a variety of different environments including hospitals. These agents damage several cellular molecules and can cause cell death. Therefore, bacteria adapt to these harsh conditions by altering gene expression and eliciting several stress responses to survive under oxidative stress. Here, we used PubMed to evaluate the current knowledge on the oxidative stress responses adopted by <i>P. aeruginosa</i>. We will describe the genes that are often differently expressed under oxidative stress conditions, the pathways and proteins employed to sense and respond to oxidative stress, and how these changes in gene expression influence pathogenicity and the virulence of <i>P. aeruginosa</i>. Understanding these responses and changes in gene expression is critical to controlling bacterial pathogenicity and developing new therapeutic agents. |
| first_indexed | 2024-03-10T07:19:44Z |
| format | Article |
| id | doaj.art-e1058d3f4a82447e90cf2183b51be490 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T07:19:44Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-e1058d3f4a82447e90cf2183b51be4902023-11-22T14:43:04ZengMDPI AGPathogens2076-08172021-09-01109118710.3390/pathogens10091187Oxidative Stress Response in <i>Pseudomonas aeruginosa</i>Waleska Stephanie da Cruz Nizer0Vasily Inkovskiy1Zoya Versey2Nikola Strempel3Edana Cassol4Joerg Overhage5Department of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, CanadaDepartment of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, CanadaDepartment of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, CanadaInstitute of Functional Interfaces, Karlsruhe Institute of Technology, 76344 Karlsruhe, GermanyDepartment of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, CanadaDepartment of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, Canada<i>Pseudomonas aeruginosa</i> is a Gram-negative environmental and human opportunistic pathogen highly adapted to many different environmental conditions. It can cause a wide range of serious infections, including wounds, lungs, the urinary tract, and systemic infections. The high versatility and pathogenicity of this bacterium is attributed to its genomic complexity, the expression of several virulence factors, and its intrinsic resistance to various antimicrobials. However, to thrive and establish infection, <i>P. aeruginosa</i> must overcome several barriers. One of these barriers is the presence of oxidizing agents (e.g., hydrogen peroxide, superoxide, and hypochlorous acid) produced by the host immune system or that are commonly used as disinfectants in a variety of different environments including hospitals. These agents damage several cellular molecules and can cause cell death. Therefore, bacteria adapt to these harsh conditions by altering gene expression and eliciting several stress responses to survive under oxidative stress. Here, we used PubMed to evaluate the current knowledge on the oxidative stress responses adopted by <i>P. aeruginosa</i>. We will describe the genes that are often differently expressed under oxidative stress conditions, the pathways and proteins employed to sense and respond to oxidative stress, and how these changes in gene expression influence pathogenicity and the virulence of <i>P. aeruginosa</i>. Understanding these responses and changes in gene expression is critical to controlling bacterial pathogenicity and developing new therapeutic agents.https://www.mdpi.com/2076-0817/10/9/1187<i>Pseudomonas aeruginosa</i>oxidative stressoxidative stress responsereactive oxygen speciesreactive chlorine speciesantimicrobial resistance |
| spellingShingle | Waleska Stephanie da Cruz Nizer Vasily Inkovskiy Zoya Versey Nikola Strempel Edana Cassol Joerg Overhage Oxidative Stress Response in <i>Pseudomonas aeruginosa</i> Pathogens <i>Pseudomonas aeruginosa</i> oxidative stress oxidative stress response reactive oxygen species reactive chlorine species antimicrobial resistance |
| title | Oxidative Stress Response in <i>Pseudomonas aeruginosa</i> |
| title_full | Oxidative Stress Response in <i>Pseudomonas aeruginosa</i> |
| title_fullStr | Oxidative Stress Response in <i>Pseudomonas aeruginosa</i> |
| title_full_unstemmed | Oxidative Stress Response in <i>Pseudomonas aeruginosa</i> |
| title_short | Oxidative Stress Response in <i>Pseudomonas aeruginosa</i> |
| title_sort | oxidative stress response in i pseudomonas aeruginosa i |
| topic | <i>Pseudomonas aeruginosa</i> oxidative stress oxidative stress response reactive oxygen species reactive chlorine species antimicrobial resistance |
| url | https://www.mdpi.com/2076-0817/10/9/1187 |
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