Immunogenicity and Immunoprotection of PCV2 Virus-like Particles Incorporating Dominant T and B Cell Antigenic Epitopes Paired with CD154 Molecules in Piglets and Mice

Immunogenicity and Immunoprotection of PCV2 Virus-like Particles Incorporating Dominant T and B Cell Antigenic Epitopes Paired with CD154 Molecules in Piglets and Mice

Porcine circovirus type 2 (PCV2) is capable of causing porcine circovirus-associated disease (PCVAD) and is one of the major threats to the global pig industry. The nucleocapsid protein Cap encoded by the PCV2 ORF2 gene is an ideal antigen for the development of PCV2 subunit vaccines, and its N-term...

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Bibliographic Details
Main Authors: Keke Wu, Wenshuo Hu, Bolun Zhou, Bingke Li, Xiaowen Li, Quanhui Yan, Wenxian Chen, Yuwan Li, Hongxing Ding, Mingqiu Zhao, Shuangqi Fan, Lin Yi, Jinding Chen
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
porcine circovirus type 2 (PCV2)
capsid protein
virus-like particles (VLPs)
T and B cell antigenic epitopes
IFN-γ
IL-4
Online Access:https://www.mdpi.com/1422-0067/23/22/14126

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