Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC

Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC

In synucleinopathies such as Parkinson’s disease (PD) and dementia with Lewy body (DLB), pathological alpha-synuclein (α-syn) aggregates are found in the gastrointestinal (GI) tract as well as in the brain. In this study, using real-time quaking-induced conversion (RT-QuIC), we investigated the pres...

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Bibliographic Details
Main Authors:	Jung-Youn Han, Chaewon Shin, Young Pyo Choi
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Viruses
Subjects:	RT-QuIC alpha-synuclein synucleinopathy Parkinson’s disease
Online Access:	https://www.mdpi.com/1999-4915/13/5/759

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