Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases
Recently, muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases. Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines, especially irisin. Irisin is a polypept...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2020-01-01
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| Series: | Cardiovascular Innovations and Applications |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2019.0569 |
| _version_ | 1797793548216565760 |
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| author | Lutfu Askin Kader Eliz Uzel Okan Tanriverdi Serdar Turkmen |
| author_facet | Lutfu Askin Kader Eliz Uzel Okan Tanriverdi Serdar Turkmen |
| author_sort | Lutfu Askin |
| collection | DOAJ |
| description | Recently, muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases. Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines, especially irisin. Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues. Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defined by homeostatic model assessment. Irisin reduces endothelial damage by inhibiting inflammation and oxidative stress, thus playing a key role in maintaining endothelial cell function. Unsurprisingly, low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis. We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases. |
| first_indexed | 2024-03-13T02:48:55Z |
| format | Article |
| id | doaj.art-e10713f51cdb4ab28e1ed06344e4f510 |
| institution | Directory Open Access Journal |
| issn | 2009-8618 2009-8782 |
| language | English |
| last_indexed | 2024-03-13T02:48:55Z |
| publishDate | 2020-01-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Cardiovascular Innovations and Applications |
| spelling | doaj.art-e10713f51cdb4ab28e1ed06344e4f5102023-06-28T14:07:27ZengCompuscript LtdCardiovascular Innovations and Applications2009-86182009-87822020-01-014319510.15212/CVIA.2019.0569Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular DiseasesLutfu AskinKader Eliz UzelOkan TanriverdiSerdar TurkmenRecently, muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases. Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines, especially irisin. Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues. Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defined by homeostatic model assessment. Irisin reduces endothelial damage by inhibiting inflammation and oxidative stress, thus playing a key role in maintaining endothelial cell function. Unsurprisingly, low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis. We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases.https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2019.0569 |
| spellingShingle | Lutfu Askin Kader Eliz Uzel Okan Tanriverdi Serdar Turkmen Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases Cardiovascular Innovations and Applications |
| title | Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases |
| title_full | Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases |
| title_fullStr | Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases |
| title_full_unstemmed | Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases |
| title_short | Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular Diseases |
| title_sort | serum irisin pathogenesis and clinical research in cardiovascular diseases |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2019.0569 |
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