Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells
Balenine is one of the endogenous imidazole dipeptides derived from marine products. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles of marine organisms. The physiological functions of dietary balenine are not well-known. In this study, we investigated whet...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/20/5/313 |
| _version_ | 1827668239365177344 |
|---|---|
| author | Min Yang Luchuanyang Sun Yasunosuke Kawabata Fumihito Murayama Takahiro Maegawa Takeshi Nikawa Katsuya Hirasaka |
| author_facet | Min Yang Luchuanyang Sun Yasunosuke Kawabata Fumihito Murayama Takahiro Maegawa Takeshi Nikawa Katsuya Hirasaka |
| author_sort | Min Yang |
| collection | DOAJ |
| description | Balenine is one of the endogenous imidazole dipeptides derived from marine products. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles of marine organisms. The physiological functions of dietary balenine are not well-known. In this study, we investigated whether the supplementation of dietary balenine was associated with muscle function in a cardiotoxin-indued muscle degeneration/regeneration model. Through morphological observation, we found that the supplementation of balenine-enriched extract promoted the regeneration stage. In addition, the expression of regeneration-related myogenic marker genes, such as paired box protein 7, MyoD1, myogenin, and Myh3, in a group of mice fed a balenine-enriched extract diet was higher than that in a group fed a normal diet. Moreover, the supplementation of balenine-enriched extract promoted the expression of anti-inflammatory cytokines as well as pro-inflammatory cytokines at the degeneration stage. Interestingly, phagocytic activity in the balenine group was significantly higher than that in the control group in vitro. These results suggest that balenine may promote the progress of muscle regeneration by increasing the phagocytic activity of macrophages. |
| first_indexed | 2024-03-10T03:32:19Z |
| format | Article |
| id | doaj.art-e1077da4d80e49c1b3f88fcc0dbae979 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T03:32:19Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-e1077da4d80e49c1b3f88fcc0dbae9792023-11-23T11:54:25ZengMDPI AGMarine Drugs1660-33972022-05-0120531310.3390/md20050313Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune CellsMin Yang0Luchuanyang Sun1Yasunosuke Kawabata2Fumihito Murayama3Takahiro Maegawa4Takeshi Nikawa5Katsuya Hirasaka6Graduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki 8528521, JapanGraduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki 8528521, JapanKyokuyo Co., Ltd., Siogama 9850001, JapanKyokuyo Co., Ltd., Siogama 9850001, JapanKyokuyo Co., Ltd., Siogama 9850001, JapanDepartment of Nutritional Physiology, Institute of Medical Nutrition, Tokushima University Medical School, Tokushima 7708503, JapanGraduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki 8528521, JapanBalenine is one of the endogenous imidazole dipeptides derived from marine products. It is composed of beta-alanine and 3-methyl-L-histidine, which exist mainly in the muscles of marine organisms. The physiological functions of dietary balenine are not well-known. In this study, we investigated whether the supplementation of dietary balenine was associated with muscle function in a cardiotoxin-indued muscle degeneration/regeneration model. Through morphological observation, we found that the supplementation of balenine-enriched extract promoted the regeneration stage. In addition, the expression of regeneration-related myogenic marker genes, such as paired box protein 7, MyoD1, myogenin, and Myh3, in a group of mice fed a balenine-enriched extract diet was higher than that in a group fed a normal diet. Moreover, the supplementation of balenine-enriched extract promoted the expression of anti-inflammatory cytokines as well as pro-inflammatory cytokines at the degeneration stage. Interestingly, phagocytic activity in the balenine group was significantly higher than that in the control group in vitro. These results suggest that balenine may promote the progress of muscle regeneration by increasing the phagocytic activity of macrophages.https://www.mdpi.com/1660-3397/20/5/313baleninemuscle regenerationdipeptideinflammationphagocytic activity |
| spellingShingle | Min Yang Luchuanyang Sun Yasunosuke Kawabata Fumihito Murayama Takahiro Maegawa Takeshi Nikawa Katsuya Hirasaka Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells Marine Drugs balenine muscle regeneration dipeptide inflammation phagocytic activity |
| title | Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells |
| title_full | Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells |
| title_fullStr | Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells |
| title_full_unstemmed | Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells |
| title_short | Balenine, Imidazole Dipeptide Promotes Skeletal Muscle Regeneration by Regulating Phagocytosis Properties of Immune Cells |
| title_sort | balenine imidazole dipeptide promotes skeletal muscle regeneration by regulating phagocytosis properties of immune cells |
| topic | balenine muscle regeneration dipeptide inflammation phagocytic activity |
| url | https://www.mdpi.com/1660-3397/20/5/313 |
| work_keys_str_mv | AT minyang balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells AT luchuanyangsun balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells AT yasunosukekawabata balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells AT fumihitomurayama balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells AT takahiromaegawa balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells AT takeshinikawa balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells AT katsuyahirasaka balenineimidazoledipeptidepromotesskeletalmuscleregenerationbyregulatingphagocytosispropertiesofimmunecells |