Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases
Pathogenic oral biofilms are now recognized as a key virulence factor in many microorganisms that cause the heavy burden of oral infectious diseases. Recently, new investigations in the nanotechnology field have propelled the development of novel biomaterials and approaches to control bacterial biof...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/10/1435 |
| _version_ | 1797515249780260864 |
|---|---|
| author | Shima Afrasiabi Nasim Chiniforush Hamid Reza Barikani Alireza Partoazar Ramin Goudarzi |
| author_facet | Shima Afrasiabi Nasim Chiniforush Hamid Reza Barikani Alireza Partoazar Ramin Goudarzi |
| author_sort | Shima Afrasiabi |
| collection | DOAJ |
| description | Pathogenic oral biofilms are now recognized as a key virulence factor in many microorganisms that cause the heavy burden of oral infectious diseases. Recently, new investigations in the nanotechnology field have propelled the development of novel biomaterials and approaches to control bacterial biofilms, either independently or in combination with other substances such as drugs, bioactive molecules, and photosensitizers used in antimicrobial photodynamic therapy (aPDT) to target different cells. Moreover, nanoparticles (NPs) showed some interesting capacity to reverse microbial dysbiosis, which is a major problem in oral biofilm formation. This review provides a perspective on oral bacterial biofilms targeted with NP-mediated treatment approaches. The first section aims to investigate the effect of NPs targeting oral bacterial biofilms. The second part of this review focuses on the application of NPs in aPDT and drug delivery systems. |
| first_indexed | 2024-03-10T06:42:50Z |
| format | Article |
| id | doaj.art-e107ebd0892c4c82aa36a767fe699aef |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T06:42:50Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e107ebd0892c4c82aa36a767fe699aef2023-11-22T17:31:53ZengMDPI AGBiomedicines2227-90592021-10-01910143510.3390/biomedicines9101435Nanostructures as Targeted Therapeutics for Combating Oral Bacterial DiseasesShima Afrasiabi0Nasim Chiniforush1Hamid Reza Barikani2Alireza Partoazar3Ramin Goudarzi4Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, IranLaser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, IranDental Implant Research Center, Dental Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, IranExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran 1441987566, IranDivision of Research and Development, Pharmin USA, LLC, San Jose, CA 95128, USAPathogenic oral biofilms are now recognized as a key virulence factor in many microorganisms that cause the heavy burden of oral infectious diseases. Recently, new investigations in the nanotechnology field have propelled the development of novel biomaterials and approaches to control bacterial biofilms, either independently or in combination with other substances such as drugs, bioactive molecules, and photosensitizers used in antimicrobial photodynamic therapy (aPDT) to target different cells. Moreover, nanoparticles (NPs) showed some interesting capacity to reverse microbial dysbiosis, which is a major problem in oral biofilm formation. This review provides a perspective on oral bacterial biofilms targeted with NP-mediated treatment approaches. The first section aims to investigate the effect of NPs targeting oral bacterial biofilms. The second part of this review focuses on the application of NPs in aPDT and drug delivery systems.https://www.mdpi.com/2227-9059/9/10/1435nanoparticleszinc oxidebiofilmsdental cariesroot canal therapyperiodontitis |
| spellingShingle | Shima Afrasiabi Nasim Chiniforush Hamid Reza Barikani Alireza Partoazar Ramin Goudarzi Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases Biomedicines nanoparticles zinc oxide biofilms dental caries root canal therapy periodontitis |
| title | Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases |
| title_full | Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases |
| title_fullStr | Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases |
| title_full_unstemmed | Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases |
| title_short | Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases |
| title_sort | nanostructures as targeted therapeutics for combating oral bacterial diseases |
| topic | nanoparticles zinc oxide biofilms dental caries root canal therapy periodontitis |
| url | https://www.mdpi.com/2227-9059/9/10/1435 |
| work_keys_str_mv | AT shimaafrasiabi nanostructuresastargetedtherapeuticsforcombatingoralbacterialdiseases AT nasimchiniforush nanostructuresastargetedtherapeuticsforcombatingoralbacterialdiseases AT hamidrezabarikani nanostructuresastargetedtherapeuticsforcombatingoralbacterialdiseases AT alirezapartoazar nanostructuresastargetedtherapeuticsforcombatingoralbacterialdiseases AT ramingoudarzi nanostructuresastargetedtherapeuticsforcombatingoralbacterialdiseases |