Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
How neurodevelopmental disorder-associated risk genes are translated into spatially patterned brain vulnerabilities is unclear. Here, the authors show that disorder-specific patterns of neuroanatomical changes are aligned to brain expression maps of disease risk genes in healthy subjects.
Bibliographic Details
| Main Authors: |
Jakob Seidlitz,
Ajay Nadig,
Siyuan Liu,
Richard A. I. Bethlehem,
Petra E. Vértes,
Sarah E. Morgan,
František Váša,
Rafael Romero-Garcia,
François M. Lalonde,
Liv S. Clasen,
Jonathan D. Blumenthal,
Casey Paquola,
Boris Bernhardt,
Konrad Wagstyl,
Damon Polioudakis,
Luis de la Torre-Ubieta,
Daniel H. Geschwind,
Joan C. Han,
Nancy R. Lee,
Declan G. Murphy,
Edward T. Bullmore,
Armin Raznahan |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2020-07-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-020-17051-5
|
|---|