Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice
We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2004-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319323734 |
| _version_ | 1811328295789133824 |
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| author | Issei Komuro Masashi Ohtsuka |
| author_facet | Issei Komuro Masashi Ohtsuka |
| author_sort | Issei Komuro |
| collection | DOAJ |
| description | We used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury. Keywords:: Na+/Ca2+ exchanger (NCX), knockout mouse, heart, ischemia/reperfusion injury |
| first_indexed | 2024-04-13T15:23:49Z |
| format | Article |
| id | doaj.art-e10ddad43a8a4249b38ff5d006cfb83f |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T15:23:49Z |
| publishDate | 2004-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-e10ddad43a8a4249b38ff5d006cfb83f2022-12-22T02:41:35ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-019612326Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout MiceIssei Komuro0Masashi Ohtsuka1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; Corresponding author. FAX: +81-43-226-2557 E-mail: komuro-tky@umin.ac.jpDepartment of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, JapanWe used Na+/Ca2+ exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mouse hearts after ischemia/reperfusion and the infracted size was significantly smaller in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury, and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury. Keywords:: Na+/Ca2+ exchanger (NCX), knockout mouse, heart, ischemia/reperfusion injuryhttp://www.sciencedirect.com/science/article/pii/S1347861319323734 |
| spellingShingle | Issei Komuro Masashi Ohtsuka Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice Journal of Pharmacological Sciences |
| title | Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice |
| title_full | Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice |
| title_fullStr | Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice |
| title_full_unstemmed | Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice |
| title_short | Forefront of Na+/Ca2+ Exchanger Studies: Role of Na+/Ca2+ Exchanger – Lessons From Knockout Mice |
| title_sort | forefront of na ca2 exchanger studies role of na ca2 exchanger lessons from knockout mice |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319323734 |
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