Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis

Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis

Drug-seeking in opioid dependence is due in part to the severe negative emotion associated with the withdrawal syndrome. It is well-established that negative emotional states emerge from activity in the amygdala. More recently, gut microflora have been shown to contribute substantially to such emoti...

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Bibliographic Details
Main Authors: Sean J. O’Sullivan, Evangelia Malahias, James Park, Ankita Srivastava, Beverly A. S. Reyes, Jon Gorky, Rajanikanth Vadigepalli, Elisabeth J. Van Bockstaele, James S. Schwaber
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroscience
Subjects:
opioid dependence
addiction
withdrawal
inflammation
amygdala
single-cell gene expression
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00665/full

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