The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR

The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR

Abstract Background Radiotherapy is one of the main treatments for pancreatic cancer, but radiation resistance limits its clinical application. As a result, novel therapeutic agents to improve radiosensitivity are urgently needed. This study aimed to investigate the effect of Ibr-7 (a derivative of...

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Bibliographic Details
Main Authors: Biqin Tan, Rong Dong, Bo Zhang, Youyou Yan, Qingyu Li, Fei Wang, Nengming Lin
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cancer Cell International
Subjects:
Pancreatic cancer
Ibr-7
Radiosensitivity
Apoptosis
EGFR
Online Access:http://link.springer.com/article/10.1186/s12935-020-01548-6

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