Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds
Background: Surgical wounds in diabetic patients still remain a problem till the present day. As a common plant found around the world, Hypericum perforatum L. (Hypericaceae) is traditionally prepared as an oily extract and used as a folk remedy for various diseases such as wounds, burns, cuts, etc....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
|
| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2016.1272654 |
| _version_ | 1827817245396434944 |
|---|---|
| author | Mehmet Altıparmak Teoman Eskitaşçıoğlu |
| author_facet | Mehmet Altıparmak Teoman Eskitaşçıoğlu |
| author_sort | Mehmet Altıparmak |
| collection | DOAJ |
| description | Background: Surgical wounds in diabetic patients still remain a problem till the present day. As a common plant found around the world, Hypericum perforatum L. (Hypericaceae) is traditionally prepared as an oily extract and used as a folk remedy for various diseases such as wounds, burns, cuts, etc. This study aims to evaluate the effect of St. John's wort (Hypericum perforatum) on problematic wounds while comparing oral and topical applications. Methods: Incisional and excisional wound models were made on the dorsal regions of 54 diabetic Spraque–Dawley rats. The rats were divided into the following six groups (n = 9): Group 1: control, Group 2: diabetic, Group 3: diabetic oral Hypericum perforatum, Group 4: diabetic topical Hypericum perforatum, Group 5: diabetic oral olive oil, and Group 6: diabetic topical olive oil. Results: Groups 3 and 4 had significantly higher tensile strength, tissue hydroxyproline concentration, and collagen density compared with Group 2. Inflammatory cell density and collagen density on day 3 were significantly higher in Groups 3 and 6 compared with Group 2. On day 21, Groups 3 and 6 had significantly higher fibroblastic activity compared with Group 2. Conclusions: This study has proved that oral St. John's wort has more positive effects on problematic wounds compared with topical St. John's wort and olive oil, which is a vehicle. Hypericum perforatum results with faster inflammatory response and better healing. These results could be an addition to literature about the clinical usage of Hypericum perforatum on diabetic wounds. |
| first_indexed | 2024-03-12T00:32:39Z |
| format | Article |
| id | doaj.art-e10f421048864a9881e3f50d76e2920c |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:32:39Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-e10f421048864a9881e3f50d76e2920c2023-09-15T10:12:27ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532018-01-01311293710.1080/08941939.2016.12726541272654Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical WoundsMehmet Altıparmak0Teoman Eskitaşçıoğlu1Reconstructive and Aesthetic SurgeryReconstructive and Aesthetic SurgeryBackground: Surgical wounds in diabetic patients still remain a problem till the present day. As a common plant found around the world, Hypericum perforatum L. (Hypericaceae) is traditionally prepared as an oily extract and used as a folk remedy for various diseases such as wounds, burns, cuts, etc. This study aims to evaluate the effect of St. John's wort (Hypericum perforatum) on problematic wounds while comparing oral and topical applications. Methods: Incisional and excisional wound models were made on the dorsal regions of 54 diabetic Spraque–Dawley rats. The rats were divided into the following six groups (n = 9): Group 1: control, Group 2: diabetic, Group 3: diabetic oral Hypericum perforatum, Group 4: diabetic topical Hypericum perforatum, Group 5: diabetic oral olive oil, and Group 6: diabetic topical olive oil. Results: Groups 3 and 4 had significantly higher tensile strength, tissue hydroxyproline concentration, and collagen density compared with Group 2. Inflammatory cell density and collagen density on day 3 were significantly higher in Groups 3 and 6 compared with Group 2. On day 21, Groups 3 and 6 had significantly higher fibroblastic activity compared with Group 2. Conclusions: This study has proved that oral St. John's wort has more positive effects on problematic wounds compared with topical St. John's wort and olive oil, which is a vehicle. Hypericum perforatum results with faster inflammatory response and better healing. These results could be an addition to literature about the clinical usage of Hypericum perforatum on diabetic wounds.http://dx.doi.org/10.1080/08941939.2016.1272654diabetic woundswound healinghypericum perforatumst john's wortsurgical woundexperimental |
| spellingShingle | Mehmet Altıparmak Teoman Eskitaşçıoğlu Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds Journal of Investigative Surgery diabetic wounds wound healing hypericum perforatum st john's wort surgical wound experimental |
| title | Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds |
| title_full | Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds |
| title_fullStr | Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds |
| title_full_unstemmed | Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds |
| title_short | Comparison of Systemic and Topical Hypericum Perforatum on Diabetic Surgical Wounds |
| title_sort | comparison of systemic and topical hypericum perforatum on diabetic surgical wounds |
| topic | diabetic wounds wound healing hypericum perforatum st john's wort surgical wound experimental |
| url | http://dx.doi.org/10.1080/08941939.2016.1272654 |
| work_keys_str_mv | AT mehmetaltıparmak comparisonofsystemicandtopicalhypericumperforatumondiabeticsurgicalwounds AT teomaneskitascıoglu comparisonofsystemicandtopicalhypericumperforatumondiabeticsurgicalwounds |