Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary
Background: Liver transplant recipients are at lifelong risk of immunosuppression-related cutaneous complications, such as malignancy and infection. Objective: Our study aims to assess the epidemiology of dermatologic conditions among liver transplant recipients in an academic medical center in Sing...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-09-01
|
| Series: | JAAD International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328721000407 |
| _version_ | 1818718603246043136 |
|---|---|
| author | Bertrand ShengYang Lian, MBBS, MRCP Thinesh Lee Krishnamoorthy, MBChB, MRCP Choon Chiat Oh, MBBS, MSc, MCI, FRCP |
| author_facet | Bertrand ShengYang Lian, MBBS, MRCP Thinesh Lee Krishnamoorthy, MBChB, MRCP Choon Chiat Oh, MBBS, MSc, MCI, FRCP |
| author_sort | Bertrand ShengYang Lian, MBBS, MRCP |
| collection | DOAJ |
| description | Background: Liver transplant recipients are at lifelong risk of immunosuppression-related cutaneous complications, such as malignancy and infection. Objective: Our study aims to assess the epidemiology of dermatologic conditions among liver transplant recipients in an academic medical center in Singapore. Methods: Medical records of liver transplant recipients on follow-up with gastroenterology and dermatology departments at the Singapore General Hospital between 2006 and 2021 were retrospectively reviewed. A literature review was subsequently performed on the keywords “liver transplant” and “dermatology.” Results: A total of 99 liver transplant recipients were identified in this study. Sixty-nine patients (70%) had at least 1 dermatologic condition. Inflammatory skin conditions were the most common (53%), followed by cutaneous infection (36%) and benign cutaneous tumors (30%). Malignant and premalignant lesions were the least common skin conditions reported (10%). Our study results concurred with many other studies reported worldwide, demonstrating a low cutaneous malignancy burden after liver transplantation. Limitations: The study included a small population size in a single center and did not have a pre-existing protocol for pretransplant dermatologic surveillance. Conclusion: Although the incidence of skin cancer after liver transplant in Singapore is low, the patients will benefit from long-term dermatology surveillance, given the long-term risks of infection and malignant skin conditions. |
| first_indexed | 2024-12-17T19:53:40Z |
| format | Article |
| id | doaj.art-e1142361c9754e8fbed9429ff1f0a759 |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-12-17T19:53:40Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-e1142361c9754e8fbed9429ff1f0a7592022-12-21T21:34:40ZengElsevierJAAD International2666-32872021-09-0147078Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule SummaryBertrand ShengYang Lian, MBBS, MRCP0Thinesh Lee Krishnamoorthy, MBChB, MRCP1Choon Chiat Oh, MBBS, MSc, MCI, FRCP2Department of Dermatology, Singapore General Hospital, SingaporeDepartment of Gastroenterology and Hepatology, Singapore General Hospital, SingaporeDepartment of Dermatology, Singapore General Hospital, Singapore; Correspondence to: Choon Chiat Oh, MBBS, MSc, MCI, FRCP, Department of Dermatology, Singapore General Hospital, Outram Road, Singapore 169608.Background: Liver transplant recipients are at lifelong risk of immunosuppression-related cutaneous complications, such as malignancy and infection. Objective: Our study aims to assess the epidemiology of dermatologic conditions among liver transplant recipients in an academic medical center in Singapore. Methods: Medical records of liver transplant recipients on follow-up with gastroenterology and dermatology departments at the Singapore General Hospital between 2006 and 2021 were retrospectively reviewed. A literature review was subsequently performed on the keywords “liver transplant” and “dermatology.” Results: A total of 99 liver transplant recipients were identified in this study. Sixty-nine patients (70%) had at least 1 dermatologic condition. Inflammatory skin conditions were the most common (53%), followed by cutaneous infection (36%) and benign cutaneous tumors (30%). Malignant and premalignant lesions were the least common skin conditions reported (10%). Our study results concurred with many other studies reported worldwide, demonstrating a low cutaneous malignancy burden after liver transplantation. Limitations: The study included a small population size in a single center and did not have a pre-existing protocol for pretransplant dermatologic surveillance. Conclusion: Although the incidence of skin cancer after liver transplant in Singapore is low, the patients will benefit from long-term dermatology surveillance, given the long-term risks of infection and malignant skin conditions.http://www.sciencedirect.com/science/article/pii/S2666328721000407actinic keratosisbasal cell carcinomaBowen diseasecutaneous malignancydermatologyinfection |
| spellingShingle | Bertrand ShengYang Lian, MBBS, MRCP Thinesh Lee Krishnamoorthy, MBChB, MRCP Choon Chiat Oh, MBBS, MSc, MCI, FRCP Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary JAAD International actinic keratosis basal cell carcinoma Bowen disease cutaneous malignancy dermatology infection |
| title | Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary |
| title_full | Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary |
| title_fullStr | Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary |
| title_full_unstemmed | Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary |
| title_short | Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort studyCapsule Summary |
| title_sort | skin conditions in liver transplant recipients in a singapore academic medical center a retrospective cohort studycapsule summary |
| topic | actinic keratosis basal cell carcinoma Bowen disease cutaneous malignancy dermatology infection |
| url | http://www.sciencedirect.com/science/article/pii/S2666328721000407 |
| work_keys_str_mv | AT bertrandshengyanglianmbbsmrcp skinconditionsinlivertransplantrecipientsinasingaporeacademicmedicalcenteraretrospectivecohortstudycapsulesummary AT thineshleekrishnamoorthymbchbmrcp skinconditionsinlivertransplantrecipientsinasingaporeacademicmedicalcenteraretrospectivecohortstudycapsulesummary AT choonchiatohmbbsmscmcifrcp skinconditionsinlivertransplantrecipientsinasingaporeacademicmedicalcenteraretrospectivecohortstudycapsulesummary |