Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer
Abstract There is uncertainty regarding the benefits and drawbacks of various radiation protocols for the treatment of left-sided breast cancer. To address this issue, we conducted a Bayesian network analysis. First, we searched several electronic databases for eligible literature. Next, we pooled t...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40577-9 |
| _version_ | 1797559868291284992 |
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| author | Yongkai Lu Yanfang Ma Di Yang Yi Li Wei Yuan Fengwen Tang Lei Xu Luping Zhou Hao Lin Binglin Li Ruijuan Chen Chenchen He Dongli Zhao |
| author_facet | Yongkai Lu Yanfang Ma Di Yang Yi Li Wei Yuan Fengwen Tang Lei Xu Luping Zhou Hao Lin Binglin Li Ruijuan Chen Chenchen He Dongli Zhao |
| author_sort | Yongkai Lu |
| collection | DOAJ |
| description | Abstract There is uncertainty regarding the benefits and drawbacks of various radiation protocols for the treatment of left-sided breast cancer. To address this issue, we conducted a Bayesian network analysis. First, we searched several electronic databases for eligible literature. Next, we pooled the data from twelve studies concerning three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT), combined with either deep inspiratory breath-holding (DIBH) or free-breathing (FB) modalities. The integrated cardiac and pulmonary dosimetric indexes for all included treatments were compared using Bayesian networks. A direct meta-analysis indicated that for the two methods of 3D-CRT and IMRT, DIBH technology was more effective than FB in reducing the radiation dose to the heart and lungs. Additionally, according to the network results, DIBH was superior to FB in all six treatment options, regardless of whether the plan was 3D-CRT, IMRT, or VMAT. Besides, the combined data indicated that the FB-3D-CRT regimen had the weakest dosimetric advantage of all the treatments. Excluding FB-3D-CRT, each of the other five treatments had its own specific benefits. This is the first Bayesian study of several radiotherapy regimens for breast cancer patients on the left side, and the findings can be used to select appropriate radiotherapy programs for breast cancer patients. |
| first_indexed | 2024-03-10T17:52:18Z |
| format | Article |
| id | doaj.art-e1149c6434614f31b600d7d9c38285b0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:52:18Z |
| publishDate | 2023-08-01 |
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| spelling | doaj.art-e1149c6434614f31b600d7d9c38285b02023-11-20T09:20:41ZengNature PortfolioScientific Reports2045-23222023-08-0113111110.1038/s41598-023-40577-9Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancerYongkai Lu0Yanfang Ma1Di Yang2Yi Li3Wei Yuan4Fengwen Tang5Lei Xu6Luping Zhou7Hao Lin8Binglin Li9Ruijuan Chen10Chenchen He11Dongli Zhao12Department of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, Shaanxi Provincial Tumor Hospital, Affiliated Hospital of Xi’an Jiaotong University Health Science CenterDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Thoracic Surgery, Xi’an Central HospitalDepartment of Thoracic Surgery, Xi’an Central HospitalDepartment of Thoracic Surgery, Xi’an Central HospitalDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiation Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract There is uncertainty regarding the benefits and drawbacks of various radiation protocols for the treatment of left-sided breast cancer. To address this issue, we conducted a Bayesian network analysis. First, we searched several electronic databases for eligible literature. Next, we pooled the data from twelve studies concerning three-dimensional conformal radiation therapy (3D-CRT), intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT), combined with either deep inspiratory breath-holding (DIBH) or free-breathing (FB) modalities. The integrated cardiac and pulmonary dosimetric indexes for all included treatments were compared using Bayesian networks. A direct meta-analysis indicated that for the two methods of 3D-CRT and IMRT, DIBH technology was more effective than FB in reducing the radiation dose to the heart and lungs. Additionally, according to the network results, DIBH was superior to FB in all six treatment options, regardless of whether the plan was 3D-CRT, IMRT, or VMAT. Besides, the combined data indicated that the FB-3D-CRT regimen had the weakest dosimetric advantage of all the treatments. Excluding FB-3D-CRT, each of the other five treatments had its own specific benefits. This is the first Bayesian study of several radiotherapy regimens for breast cancer patients on the left side, and the findings can be used to select appropriate radiotherapy programs for breast cancer patients.https://doi.org/10.1038/s41598-023-40577-9 |
| spellingShingle | Yongkai Lu Yanfang Ma Di Yang Yi Li Wei Yuan Fengwen Tang Lei Xu Luping Zhou Hao Lin Binglin Li Ruijuan Chen Chenchen He Dongli Zhao Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer Scientific Reports |
| title | Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer |
| title_full | Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer |
| title_fullStr | Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer |
| title_full_unstemmed | Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer |
| title_short | Cardiorespiratory dose comparison among six radiotherapy regimens for patients with left-sided breast cancer |
| title_sort | cardiorespiratory dose comparison among six radiotherapy regimens for patients with left sided breast cancer |
| url | https://doi.org/10.1038/s41598-023-40577-9 |
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