Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study
Abstract Background Among people living with HIV (PLWH), the prevalence of non-HIV related co-morbidities is increasing. Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the potential disease-disease interactions in a cohort of Italian HIV patients....
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4184-z |
| _version_ | 1818285397972615168 |
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| author | Paolo Maggi Carmen R. Santoro Marco Nofri Elena Ricci Nicolò De Gennaro Chiara Bellacosa Elisabetta Schiaroli Giancarlo Orofino Barbara Menzaghi Antonio Di Biagio Nicola Squillace Daniela Francisci Francesca Vichi Chiara Molteni Paolo Bonfanti Giovanni Battista Gaeta Giuseppe Vittorio De Socio |
| author_facet | Paolo Maggi Carmen R. Santoro Marco Nofri Elena Ricci Nicolò De Gennaro Chiara Bellacosa Elisabetta Schiaroli Giancarlo Orofino Barbara Menzaghi Antonio Di Biagio Nicola Squillace Daniela Francisci Francesca Vichi Chiara Molteni Paolo Bonfanti Giovanni Battista Gaeta Giuseppe Vittorio De Socio |
| author_sort | Paolo Maggi |
| collection | DOAJ |
| description | Abstract Background Among people living with HIV (PLWH), the prevalence of non-HIV related co-morbidities is increasing. Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the potential disease-disease interactions in a cohort of Italian HIV patients. Methods Cross-sectional analysis conducted by the Coordinamento Italiano per lo Studio di Allergia e Infezioni da HIV (CISAI) on adult subjects attending HIV-outpatient facilities. Non-HIV co-morbidities included: cardiovascular disease, diabetes mellitus, hypertension, oncologic diseases, osteoporosis, probable case of chronic obstructive pulmonary disease (COPD), hepatitis C virus (HCV) infection, psychiatric illness, kidney disease. Multi-morbidity was defined as the presence of two or more co-morbidities. Results One thousand and eighty-seven patients were enrolled in the study (mean age 47.9 ± 10.8). One hundred-ninety patients (17.5%) had no co-morbidity, whereas 285 (26.2%) had one condition and 612 (56.3%) were multi-morbid. The most recurrent associations were: 1) dyslipidemia + hypertension (237, 21.8%); 2) dyslipidemia + COPD (188, 17.3%); 3) COPD + HCV-Ab+ (141, 12.9%). Multi-morbidity was associated with older age, higher body mass index, current and former smoking, CDC stage C and longer ART duration. Conclusions More than 50% of PLHW were multi-morbid and about 30% had three or more concurrent comorbidities. The identification of common patterns of comorbidities address the combined risks of multiple drug and disease-disease interactions. |
| first_indexed | 2024-12-13T01:08:03Z |
| format | Article |
| id | doaj.art-e114ea047c8e49c5baedbc7553bf922d |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T01:08:03Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-e114ea047c8e49c5baedbc7553bf922d2022-12-22T00:04:32ZengBMCBMC Infectious Diseases1471-23342019-06-011911910.1186/s12879-019-4184-zClusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional studyPaolo Maggi0Carmen R. Santoro1Marco Nofri2Elena Ricci3Nicolò De Gennaro4Chiara Bellacosa5Elisabetta Schiaroli6Giancarlo Orofino7Barbara Menzaghi8Antonio Di Biagio9Nicola Squillace10Daniela Francisci11Francesca Vichi12Chiara Molteni13Paolo Bonfanti14Giovanni Battista Gaeta15Giuseppe Vittorio De Socio16Infectious Diseases Clinic University of Campania “Luigi Vanvitelli”Infectious Diseases Clinic, University of BariInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria HospitalDepartment of Women, Child and Neonate, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoInfectious Diseases Clinic, University of BariInfectious Diseases Clinic, University of BariInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria HospitalDivision I of Infectious and Tropical Diseases, ASL Città di TorinoUnit of Infectious Diseases, ASST della Valle OlonaInfectious Diseases, San Martino Hospital GenoaInfectious Diseases Unit ASST-MONZA, San Gerardo Hospital-University of Milano-BicoccaInfectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria HospitalInfectious Diseases Unit, Santa Maria Annunziata Hospital, Usl centroUnit of Infectious Diseases, A. Manzoni HospitalUnit of Infectious Diseases, A. Manzoni HospitalInfectious Diseases Clinic University of Campania “Luigi Vanvitelli”Infectious Diseases Clinic, Department of Medicine 2, Azienda Ospedaliera di Perugia and University of Perugia, Santa Maria HospitalAbstract Background Among people living with HIV (PLWH), the prevalence of non-HIV related co-morbidities is increasing. Aim of the present study is to describe co-morbidity and multi-morbidity, their clustering mode and the potential disease-disease interactions in a cohort of Italian HIV patients. Methods Cross-sectional analysis conducted by the Coordinamento Italiano per lo Studio di Allergia e Infezioni da HIV (CISAI) on adult subjects attending HIV-outpatient facilities. Non-HIV co-morbidities included: cardiovascular disease, diabetes mellitus, hypertension, oncologic diseases, osteoporosis, probable case of chronic obstructive pulmonary disease (COPD), hepatitis C virus (HCV) infection, psychiatric illness, kidney disease. Multi-morbidity was defined as the presence of two or more co-morbidities. Results One thousand and eighty-seven patients were enrolled in the study (mean age 47.9 ± 10.8). One hundred-ninety patients (17.5%) had no co-morbidity, whereas 285 (26.2%) had one condition and 612 (56.3%) were multi-morbid. The most recurrent associations were: 1) dyslipidemia + hypertension (237, 21.8%); 2) dyslipidemia + COPD (188, 17.3%); 3) COPD + HCV-Ab+ (141, 12.9%). Multi-morbidity was associated with older age, higher body mass index, current and former smoking, CDC stage C and longer ART duration. Conclusions More than 50% of PLHW were multi-morbid and about 30% had three or more concurrent comorbidities. The identification of common patterns of comorbidities address the combined risks of multiple drug and disease-disease interactions.http://link.springer.com/article/10.1186/s12879-019-4184-zHIVCo-morbidityMulti-morbidityDisease-disease interactionsClusterization |
| spellingShingle | Paolo Maggi Carmen R. Santoro Marco Nofri Elena Ricci Nicolò De Gennaro Chiara Bellacosa Elisabetta Schiaroli Giancarlo Orofino Barbara Menzaghi Antonio Di Biagio Nicola Squillace Daniela Francisci Francesca Vichi Chiara Molteni Paolo Bonfanti Giovanni Battista Gaeta Giuseppe Vittorio De Socio Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study BMC Infectious Diseases HIV Co-morbidity Multi-morbidity Disease-disease interactions Clusterization |
| title | Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study |
| title_full | Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study |
| title_fullStr | Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study |
| title_full_unstemmed | Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study |
| title_short | Clusterization of co-morbidities and multi-morbidities among persons living with HIV: a cross-sectional study |
| title_sort | clusterization of co morbidities and multi morbidities among persons living with hiv a cross sectional study |
| topic | HIV Co-morbidity Multi-morbidity Disease-disease interactions Clusterization |
| url | http://link.springer.com/article/10.1186/s12879-019-4184-z |
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