Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis
ObjectiveMajor depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluc...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1146944/full |
| _version_ | 1797895441357996032 |
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| author | Yang Zhou Yang Zhou Yu Song Yu Song Cheng Chen Cheng Chen Shu Yan Shu Yan Mo Chen Mo Chen Tao Liu |
| author_facet | Yang Zhou Yang Zhou Yu Song Yu Song Cheng Chen Cheng Chen Shu Yan Shu Yan Mo Chen Mo Chen Tao Liu |
| author_sort | Yang Zhou |
| collection | DOAJ |
| description | ObjectiveMajor depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluctuation (ALFF) results as a neuroimaging biomarker for aiding the diagnosis of MDD with SA in adolescents.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) analyses of 71 first-episode, drug-naive adolescent MDD patients with SA and 54 healthy control individuals were conducted. ALFF and SVM methods were used to analyze the imaging data.ResultsRelative to healthy control individuals, adolescent MDD patients with a history of SAs showed reduced ALFF values in the bilateral medial superior frontal gyrus (mSFG) and bilateral precuneus. These lower ALFF values were also negatively correlated with child depression inventory (CDI) scores while reduced bilateral precuneus ALFF values were negatively correlated with Suicidal Ideation Questionnaire Junior (SIQ-JR) scores. SVM analyses showed that reduced ALFF values in the bilateral mSFG and bilateral precuneus had diagnostic accuracy levels of 76.8% (96/125) and 82.4% (103/125), respectively.ConclusionAdolescent MDD patients with a history of SA exhibited abnormal ALFF. The identified abnormalities in specific brain regions may be involved in the pathogenesis of this condition and may help identify at-risk adolescents. Specifically, reductions in the ALFF in the bilateral mSFG and bilateral precuneus may be indicative of MDD and SA in adolescent patients. |
| first_indexed | 2024-04-10T07:25:37Z |
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| id | doaj.art-e115a04a1ac24d4898b8ea80b4f12634 |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-10T07:25:37Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychology |
| spelling | doaj.art-e115a04a1ac24d4898b8ea80b4f126342023-02-24T07:42:44ZengFrontiers Media S.A.Frontiers in Psychology1664-10782023-02-011410.3389/fpsyg.2023.11469441146944Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysisYang Zhou0Yang Zhou1Yu Song2Yu Song3Cheng Chen4Cheng Chen5Shu Yan6Shu Yan7Mo Chen8Mo Chen9Tao Liu10Department of Psychiatry, Wuhan Mental Health Center, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan, Hubei, ChinaPsychiatric Rehabilitation Department, Wuhan Mental Health Center, Wuhan, Hubei, ChinaPsychiatric Rehabilitation Department, Wuhan Hospital for Psychotherapy, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Mental Health Center, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Mental Health Center, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Mental Health Center, Wuhan, Hubei, ChinaDepartment of Psychiatry, Wuhan Hospital for Psychotherapy, Wuhan, Hubei, ChinaDepartment of Psychiatry, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, ChinaObjectiveMajor depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluctuation (ALFF) results as a neuroimaging biomarker for aiding the diagnosis of MDD with SA in adolescents.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) analyses of 71 first-episode, drug-naive adolescent MDD patients with SA and 54 healthy control individuals were conducted. ALFF and SVM methods were used to analyze the imaging data.ResultsRelative to healthy control individuals, adolescent MDD patients with a history of SAs showed reduced ALFF values in the bilateral medial superior frontal gyrus (mSFG) and bilateral precuneus. These lower ALFF values were also negatively correlated with child depression inventory (CDI) scores while reduced bilateral precuneus ALFF values were negatively correlated with Suicidal Ideation Questionnaire Junior (SIQ-JR) scores. SVM analyses showed that reduced ALFF values in the bilateral mSFG and bilateral precuneus had diagnostic accuracy levels of 76.8% (96/125) and 82.4% (103/125), respectively.ConclusionAdolescent MDD patients with a history of SA exhibited abnormal ALFF. The identified abnormalities in specific brain regions may be involved in the pathogenesis of this condition and may help identify at-risk adolescents. Specifically, reductions in the ALFF in the bilateral mSFG and bilateral precuneus may be indicative of MDD and SA in adolescent patients.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1146944/fullamplitude of low-frequency fluctuationmajor depressive disordersuicidal attemptsresting-state fMRIsupport vector machine |
| spellingShingle | Yang Zhou Yang Zhou Yu Song Yu Song Cheng Chen Cheng Chen Shu Yan Shu Yan Mo Chen Mo Chen Tao Liu Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis Frontiers in Psychology amplitude of low-frequency fluctuation major depressive disorder suicidal attempts resting-state fMRI support vector machine |
| title | Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis |
| title_full | Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis |
| title_fullStr | Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis |
| title_full_unstemmed | Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis |
| title_short | Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis |
| title_sort | abnormal amplitude of low frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents a resting state fmri and support vector machine analysis |
| topic | amplitude of low-frequency fluctuation major depressive disorder suicidal attempts resting-state fMRI support vector machine |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1146944/full |
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