Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response

Survival of HT29 Cancer Cells Is Affected by IGF1R Inhibition via Modulation of Self-DNA-Triggered TLR9 Signaling and the Autophagy Response

Purpose: In HT29 colon cancer cells, a close interplay between self-DNA-induced TLR9 signaling and autophagy response was found, with remarkable effects on cell survival and differentiation. IGF1R activation drives the development and malignant progression of colorectal cancer. IGF1R inhibition disp...

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Bibliographic Details
Main Authors: Ferenc Sipos, Bettina Bohusné Barta, Ágnes Simon, Lőrinc Nagy, Titanilla Dankó, Regina Eszter Raffay, Gábor Petővári, Viktória Zsiros, Barnabás Wichmann, Anna Sebestyén, Györgyi Műzes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Pathology and Oncology Research
Subjects:
autophagy
CD133
IGF1R
TLR9
HT29 cancer cell
self-DNA
Online Access:https://www.por-journal.com/articles/10.3389/pore.2022.1610322/full

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