Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression
Background: Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role in the interaction between the central and peripheral inflammation. Here we aimed to investigate CP volume alterations in depression and their associations with inflammation. Met...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221003703 |
| _version_ | 1819278710583328768 |
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| author | Noha Althubaity Julia Schubert Daniel Martins Tayyabah Yousaf Maria A. Nettis Valeria Mondelli Carmine Pariante Neil A. Harrison Edward T. Bullmore Danai Dima Federico E. Turkheimer Mattia Veronese |
| author_facet | Noha Althubaity Julia Schubert Daniel Martins Tayyabah Yousaf Maria A. Nettis Valeria Mondelli Carmine Pariante Neil A. Harrison Edward T. Bullmore Danai Dima Federico E. Turkheimer Mattia Veronese |
| author_sort | Noha Althubaity |
| collection | DOAJ |
| description | Background: Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role in the interaction between the central and peripheral inflammation. Here we aimed to investigate CP volume alterations in depression and their associations with inflammation. Methods: 51 depressed participants (HDRS score > 13) and 25 age- and sex-matched healthy controls (HCs) from the Wellcome Trust NIMA consortium were re-analysed for the study. All the participants underwent full peripheral cytokine profiling and simultaneous [11C]PK11195 PET/structural MRI imaging for measuring neuroinflammation and CP volume respectively. Results: We found a significantly greater CP volume in depressed subjects compared to HCs (t(76) = +2.17) that was positively correlated with [11C]PK11195 PET binding in the anterior cingulate cortex (r = 0.28, p = 0.02), prefrontal cortex (r = 0.24, p = 0.04), and insular cortex (r = 0.24, p = 0.04), but not with the peripheral inflammatory markers: CRP levels (r = 0.07, p = 0.53), IL-6 (r = -0.08, p = 0.61), and TNF-α (r = -0.06, p = 0.70). The CP volume correlated with the [11C]PK11195 PET binding in CP (r = 0.34, p = 0.005). Integration of transcriptomic data from the Allen Human Brain Atlas with the brain map depicting the correlations between CP volume and PET imaging found significant gene enrichment for several pathways involved in neuroinflammatory response. Conclusion: This result supports the hypothesis that changes in brain barriers may cause reduction in solute exchanges between blood and CSF, disturbing the brain homeostasis and ultimately contributing to inflammation in depression. Given that CP anomalies have been recently detected in other brain disorders, these results may not be specific to depression and might extend to other conditions with a peripheral inflammatory component. |
| first_indexed | 2024-12-24T00:16:20Z |
| format | Article |
| id | doaj.art-e11a9a6028d641c2b7202406cfdc0559 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-24T00:16:20Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-e11a9a6028d641c2b7202406cfdc05592022-12-21T17:24:45ZengElsevierNeuroImage: Clinical2213-15822022-01-0133102926Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depressionNoha Althubaity0Julia Schubert1Daniel Martins2Tayyabah Yousaf3Maria A. Nettis4Valeria Mondelli5Carmine Pariante6Neil A. Harrison7Edward T. Bullmore8Danai Dima9Federico E. Turkheimer10Mattia Veronese11Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Radiological Sciences, College of Applied Medical Science, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Corresponding author at: Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKCardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK; Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, UKDepartment of Psychiatry, School of Clinical Medicine, University of Cambridge, UK; Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK; Immuno-Psychiatry, Immuno-Inflammation Therapeutic Area Unit, GlaxoSmithKline R&D, Stevenage, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychology, School of Arts and Social Sciences, City University of London, London, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKDepartment of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Information Engineering, University of Padua, Padua, ItalyBackground: Recent studies have shown that choroid plexuses (CP) may be involved in the neuro-immune axes, playing a role in the interaction between the central and peripheral inflammation. Here we aimed to investigate CP volume alterations in depression and their associations with inflammation. Methods: 51 depressed participants (HDRS score > 13) and 25 age- and sex-matched healthy controls (HCs) from the Wellcome Trust NIMA consortium were re-analysed for the study. All the participants underwent full peripheral cytokine profiling and simultaneous [11C]PK11195 PET/structural MRI imaging for measuring neuroinflammation and CP volume respectively. Results: We found a significantly greater CP volume in depressed subjects compared to HCs (t(76) = +2.17) that was positively correlated with [11C]PK11195 PET binding in the anterior cingulate cortex (r = 0.28, p = 0.02), prefrontal cortex (r = 0.24, p = 0.04), and insular cortex (r = 0.24, p = 0.04), but not with the peripheral inflammatory markers: CRP levels (r = 0.07, p = 0.53), IL-6 (r = -0.08, p = 0.61), and TNF-α (r = -0.06, p = 0.70). The CP volume correlated with the [11C]PK11195 PET binding in CP (r = 0.34, p = 0.005). Integration of transcriptomic data from the Allen Human Brain Atlas with the brain map depicting the correlations between CP volume and PET imaging found significant gene enrichment for several pathways involved in neuroinflammatory response. Conclusion: This result supports the hypothesis that changes in brain barriers may cause reduction in solute exchanges between blood and CSF, disturbing the brain homeostasis and ultimately contributing to inflammation in depression. Given that CP anomalies have been recently detected in other brain disorders, these results may not be specific to depression and might extend to other conditions with a peripheral inflammatory component.http://www.sciencedirect.com/science/article/pii/S2213158221003703Choroid PlexusNeuroinflammationDepressionBlood brain barrier |
| spellingShingle | Noha Althubaity Julia Schubert Daniel Martins Tayyabah Yousaf Maria A. Nettis Valeria Mondelli Carmine Pariante Neil A. Harrison Edward T. Bullmore Danai Dima Federico E. Turkheimer Mattia Veronese Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression NeuroImage: Clinical Choroid Plexus Neuroinflammation Depression Blood brain barrier |
| title | Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression |
| title_full | Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression |
| title_fullStr | Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression |
| title_full_unstemmed | Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression |
| title_short | Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression |
| title_sort | choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression |
| topic | Choroid Plexus Neuroinflammation Depression Blood brain barrier |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221003703 |
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