Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran
Abstract Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of...
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| Format: | Article |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46262-1 |
| _version_ | 1797637009332764672 |
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| author | Majid Radfard Hassan Hashemi Mohammad Ali Baghapour Mohammad Reza Samaei Masud Yunesian Hamed Soleimani Abooalfazl Azhdarpoor |
| author_facet | Majid Radfard Hassan Hashemi Mohammad Ali Baghapour Mohammad Reza Samaei Masud Yunesian Hamed Soleimani Abooalfazl Azhdarpoor |
| author_sort | Majid Radfard |
| collection | DOAJ |
| description | Abstract Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of Fars province and evaluate the attributed burden of disease. Non-carcinogenic risk assessment was performed using the hazard quotient (HQ) method, while the carcinogenic risk assessment utilized the excess lifetime cancer risk approach. The burden of disease was evaluated in terms of years of life lost, years lived with disability, and disability-adjusted life years (DALY) for three specific cancers: skin, lung, and kidney cancer. The average drinking water concentrations of arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) were determined to be 0.72, 0.4, 1.10 and 0.72 μg/L, respectively. The total average HQ of heavy metals in drinking water in the study area were 0.127, 0.0047, 0.0009 and 0.0069, respectively. The average ILCRs of heavy metal in the entire country were in the following order: 1.15 × 10−5 for As, 2.22 × 10−7 for Cd and 3.41 × 10−7 for Cr. The results also indicated that among the various counties analyzed, Fasa experiences the greatest burden of disease in terms of DALYs, with a value of 87.56, specifically attributed to cancers caused by exposure to arsenic. Generally, it can be said that the burden of disease is a critical aspect of public health that requires comprehensive understanding and effective intervention. |
| first_indexed | 2024-03-11T12:43:13Z |
| format | Article |
| id | doaj.art-e11b14fe766e48298002e35cab882614 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T12:43:13Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e11b14fe766e48298002e35cab8826142023-11-05T12:13:18ZengNature PortfolioScientific Reports2045-23222023-11-0113111610.1038/s41598-023-46262-1Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, IranMajid Radfard0Hassan Hashemi1Mohammad Ali Baghapour2Mohammad Reza Samaei3Masud Yunesian4Hamed Soleimani5Abooalfazl Azhdarpoor6Department of Environmental Health Engineering, School of Public Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Shiraz University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Tehran University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Tehran University of Medical SciencesDepartment of Environmental Health Engineering, School of Public Health, Shiraz University of Medical SciencesAbstract Exposure to heavy metals in contaminated drinking water is strongly correlated with various cancers, highlighting the burden of disease. This study aimed to assess the non-carcinogenic and carcinogenic risks associated with exposure to heavy metals (As, Pb, Cd, and Cr) in drinking water of Fars province and evaluate the attributed burden of disease. Non-carcinogenic risk assessment was performed using the hazard quotient (HQ) method, while the carcinogenic risk assessment utilized the excess lifetime cancer risk approach. The burden of disease was evaluated in terms of years of life lost, years lived with disability, and disability-adjusted life years (DALY) for three specific cancers: skin, lung, and kidney cancer. The average drinking water concentrations of arsenic (As), cadmium (Cd), chromium (Cr) and lead (Pb) were determined to be 0.72, 0.4, 1.10 and 0.72 μg/L, respectively. The total average HQ of heavy metals in drinking water in the study area were 0.127, 0.0047, 0.0009 and 0.0069, respectively. The average ILCRs of heavy metal in the entire country were in the following order: 1.15 × 10−5 for As, 2.22 × 10−7 for Cd and 3.41 × 10−7 for Cr. The results also indicated that among the various counties analyzed, Fasa experiences the greatest burden of disease in terms of DALYs, with a value of 87.56, specifically attributed to cancers caused by exposure to arsenic. Generally, it can be said that the burden of disease is a critical aspect of public health that requires comprehensive understanding and effective intervention.https://doi.org/10.1038/s41598-023-46262-1 |
| spellingShingle | Majid Radfard Hassan Hashemi Mohammad Ali Baghapour Mohammad Reza Samaei Masud Yunesian Hamed Soleimani Abooalfazl Azhdarpoor Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran Scientific Reports |
| title | Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran |
| title_full | Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran |
| title_fullStr | Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran |
| title_full_unstemmed | Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran |
| title_short | Prediction of human health risk and disability-adjusted life years induced by heavy metals exposure through drinking water in Fars Province, Iran |
| title_sort | prediction of human health risk and disability adjusted life years induced by heavy metals exposure through drinking water in fars province iran |
| url | https://doi.org/10.1038/s41598-023-46262-1 |
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