Machine Learning Approaches to Classify Primary and Metastatic Cancers Using Tissue of Origin-Based DNA Methylation Profiles

Machine Learning Approaches to Classify Primary and Metastatic Cancers Using Tissue of Origin-Based DNA Methylation Profiles

Metastatic cancers account for up to 90% of cancer-related deaths. The clear differentiation of metastatic cancers from primary cancers is crucial for cancer type identification and developing targeted treatment for each cancer type. DNA methylation patterns are suggested to be an intriguing target...

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Bibliographic Details
Main Authors: Vijayachitra Modhukur, Shakshi Sharma, Mainak Mondal, Ankita Lawarde, Keiu Kask, Rajesh Sharma, Andres Salumets
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
DNA methylation
TCGA
biomarkers
clustering
differential methylation
metastasis
Online Access:https://www.mdpi.com/2072-6694/13/15/3768

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