Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

Microglial REV-ERBα regulates inflammation and lipid droplet formation to drive tauopathy in male mice

Abstract Alzheimer’s disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. REV-ERBα is a core circadian clock protein which also serves as a nuclear receptor and transcri...

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Bibliographic Details
Main Authors:	Jiyeon Lee, Julie M. Dimitry, Jong Hee Song, Minsoo Son, Patrick W. Sheehan, Melvin W. King, G. Travis Tabor, Young Ah Goo, Mitchell A. Lazar, Leonard Petrucelli, Erik S. Musiek
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-023-40927-1

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