Recent Progress Towards a Gonococcal Vaccine
Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection. Attempts to generate an effective vaccine for gonorrhea have thus far been unsuccessful, as many struct...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.881392/full |
| _version_ | 1819023905785905152 |
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| author | Stavros A. Maurakis Cynthia Nau Cornelissen |
| author_facet | Stavros A. Maurakis Cynthia Nau Cornelissen |
| author_sort | Stavros A. Maurakis |
| collection | DOAJ |
| description | Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection. Attempts to generate an effective vaccine for gonorrhea have thus far been unsuccessful, as many structures on the bacterial envelope have the propensity to rapidly change, thus complicating recognition by the human immune system. In response to recent efforts from global health authorities to spur the efforts towards development of a vaccine, several new and promising steps have been made towards this goal, aided by advancements in computational epitope identification and prediction methods. Here, we provide a short review of recent progress towards a viable gonococcal vaccine, with a focus on antigen identification and characterization, and discuss a few of the tools that may be important in furthering these efforts. |
| first_indexed | 2024-12-21T04:46:19Z |
| format | Article |
| id | doaj.art-e11dd6d75eb742fb98baee9d79899727 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-21T04:46:19Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-e11dd6d75eb742fb98baee9d798997272022-12-21T19:15:35ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-04-011210.3389/fcimb.2022.881392881392Recent Progress Towards a Gonococcal VaccineStavros A. MaurakisCynthia Nau CornelissenGonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection. Attempts to generate an effective vaccine for gonorrhea have thus far been unsuccessful, as many structures on the bacterial envelope have the propensity to rapidly change, thus complicating recognition by the human immune system. In response to recent efforts from global health authorities to spur the efforts towards development of a vaccine, several new and promising steps have been made towards this goal, aided by advancements in computational epitope identification and prediction methods. Here, we provide a short review of recent progress towards a viable gonococcal vaccine, with a focus on antigen identification and characterization, and discuss a few of the tools that may be important in furthering these efforts.https://www.frontiersin.org/articles/10.3389/fcimb.2022.881392/fullNeisseria gonorrhoeaegonorrheavaccinesexually-transmitted infectionsimmunityepitope |
| spellingShingle | Stavros A. Maurakis Cynthia Nau Cornelissen Recent Progress Towards a Gonococcal Vaccine Frontiers in Cellular and Infection Microbiology Neisseria gonorrhoeae gonorrhea vaccine sexually-transmitted infections immunity epitope |
| title | Recent Progress Towards a Gonococcal Vaccine |
| title_full | Recent Progress Towards a Gonococcal Vaccine |
| title_fullStr | Recent Progress Towards a Gonococcal Vaccine |
| title_full_unstemmed | Recent Progress Towards a Gonococcal Vaccine |
| title_short | Recent Progress Towards a Gonococcal Vaccine |
| title_sort | recent progress towards a gonococcal vaccine |
| topic | Neisseria gonorrhoeae gonorrhea vaccine sexually-transmitted infections immunity epitope |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.881392/full |
| work_keys_str_mv | AT stavrosamaurakis recentprogresstowardsagonococcalvaccine AT cynthianaucornelissen recentprogresstowardsagonococcalvaccine |