Risk Factors of Drug Resistance among Tuberculosis Patients of Prakasam District, Andhra Pradesh, India
Introduction: India is leading in the burden of Tuberculosis (TB) according to the new report of the World Health Organisation (WHO) on the disease. Multi-Drug Resistant TB (MDR-TB) cases have been increasing in India. About half of the world’s MDR-TB cases are present in India. Aim: To assess...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2020-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/14386/45508_CE(Ra1)_P(AK)_PF1(ShG_SL)_PN(SL).pdf |
| Summary: | Introduction: India is leading in the burden of Tuberculosis (TB)
according to the new report of the World Health Organisation
(WHO) on the disease. Multi-Drug Resistant TB (MDR-TB) cases
have been increasing in India. About half of the world’s MDR-TB
cases are present in India.
Aim: To assess the incidence of drug resistant TB in Prakasam
district, Andhra Pradesh, India, in the second quarter of the year
2019 and to determine the risk factors that are responsible to
develop drug resistance to anti-tubercular drugs in the study
population.
Materials and Methods: A Community based cross-sectional
study was conducted from April 1st to June 30th in Prakasam
district, Andhra Pradesh. All the registered drug resistant TB
cases in Prakasam district who gave consent during the study
period were taken as sample. The diagnosed drug resistant
TB patients were interviewed and proportions of different
variables were calculated and chi-square test was used to test
significance of results.
Results: Out of 209 TB patients, 88 patients were having drug
resistant TB in Prakasam district. Prevalence of Drug resistant
TB in Prakasam district was calculated as 5.64 per one lac
population. In the second quarter of the year 2019-2020,
i.e., from April 1st to June 30th, 88 new cases were identified.
Incidence of Drug resistant TB in Prakasam district was
calculated as 2.38 per one lac population. Male persons (76%),
having the age 20-40 years (42%), 40-60 (38.7%) belonging
to middle class (45.5%) and migrating for work (85%) are at
more risk of developing drug resistant TB. Most of the patients
are developing drug resistant TB directly (70.5%) which is an
alarming signal. The rifampicin resistant patients were also
developing psychological complications (22). Drug toxicity was
observed in 55% of the cases.
Conclusion: Incidence of drug resistant TB was more in male
persons, above 20 years of age, belonging to middle class
socio-economic status and migrating for work. Most of the
patients developed drug resistant TB directly without previous
history of TB. Drug toxicity was observed in half of the cases.
Psychological complications were observed in rifampicin
resistant patients. Surveillance activity should be addressed
properly to combat the risk factors. |
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| ISSN: | 2249-782X 0973-709X |