Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery
Abstract Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs. In this minireview, the functional...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2023-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100301&tlng=en |
| _version_ | 1797951343955017728 |
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| author | Dwianto Harry Nugraha Kusnandar Anggadiredja Heni Rachmawati |
| author_facet | Dwianto Harry Nugraha Kusnandar Anggadiredja Heni Rachmawati |
| author_sort | Dwianto Harry Nugraha |
| collection | DOAJ |
| description | Abstract Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs. In this minireview, the functional properties of poloxamer for physicochemical modification, such as solubility and stability, and biological response modification, such as neuroprotection, cell apoptosis, efflux pump modification, membrane cell modification, and cellular uptake, are discussed to provide a broader understanding to assist the development of poloxamer-based formulations. |
| first_indexed | 2024-04-10T22:29:04Z |
| format | Article |
| id | doaj.art-e11e70ad07034aaea8959a69336912c1 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-10T22:29:04Z |
| publishDate | 2023-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e11e70ad07034aaea8959a69336912c12023-01-17T07:34:39ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-01-015810.1590/s2175-97902022e21125Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug DeliveryDwianto Harry Nugrahahttps://orcid.org/0000-0001-7155-9707Kusnandar AnggadiredjaHeni RachmawatiAbstract Poloxamer is a biocompatible polymer that has already been approved by the US FDA for multiple applications. Poloxamer itself has many grades and functional categories that enable the improvement of both physicochemical and biological properties of drugs. In this minireview, the functional properties of poloxamer for physicochemical modification, such as solubility and stability, and biological response modification, such as neuroprotection, cell apoptosis, efflux pump modification, membrane cell modification, and cellular uptake, are discussed to provide a broader understanding to assist the development of poloxamer-based formulations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100301&tlng=enPoloxamerBiocompatiblePhysicochemical Modification and Biological Response Modification |
| spellingShingle | Dwianto Harry Nugraha Kusnandar Anggadiredja Heni Rachmawati Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery Brazilian Journal of Pharmaceutical Sciences Poloxamer Biocompatible Physicochemical Modification and Biological Response Modification |
| title | Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery |
| title_full | Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery |
| title_fullStr | Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery |
| title_full_unstemmed | Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery |
| title_short | Mini-Review of Poloxamer as a Biocompatible Polymer for Advanced Drug Delivery |
| title_sort | mini review of poloxamer as a biocompatible polymer for advanced drug delivery |
| topic | Poloxamer Biocompatible Physicochemical Modification and Biological Response Modification |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100301&tlng=en |
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