A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis
Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by chronic synovitis and articular destruction. Pain is the earliest and most important symptom. The Janus kinase/stat signaling pathway not only participates in the physiological processes such as the growth and differentia...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-08-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X231197498 |
| _version_ | 1827854419657490432 |
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| author | Yue Xiong Xiaohui Song Xiangrui Sheng Jian Wu Xin Chang Tian Ren Jin Cao Tao Cheng Mingjun Wang |
| author_facet | Yue Xiong Xiaohui Song Xiangrui Sheng Jian Wu Xin Chang Tian Ren Jin Cao Tao Cheng Mingjun Wang |
| author_sort | Yue Xiong |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by chronic synovitis and articular destruction. Pain is the earliest and most important symptom. The Janus kinase/stat signaling pathway not only participates in the physiological processes such as the growth and differentiation of normal cells, but also plays a significant role in the pathological mechanisms such as pain in RA patients. Pain in RA patients is mediated by both inflammatory and non-inflammatory factors, including central sensitization and peripheral sensitization. Cytokines can regulate the nociceptor threshold through the JAK pathway, which leads to sensitization. In this review, we provide an overview of the physiological basis of pain modulation, the underlying importance of cytokines and JAK/STAT pathway in pain modulation, and finally introduce the performance of JAK inhibitors in clinical research. Having a better understanding of the mechanism of pain in RA may provide new therapeutic ideas and directions for the clinical improvement of pain in RA patients. |
| first_indexed | 2024-03-12T11:22:24Z |
| format | Article |
| id | doaj.art-e11e8b10864449a7ad37dc8777114280 |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-03-12T11:22:24Z |
| publishDate | 2023-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-e11e8b10864449a7ad37dc87771142802023-09-01T20:33:25ZengSAGE PublishingEuropean Journal of Inflammation2058-73922023-08-012110.1177/1721727X231197498A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritisYue XiongXiaohui SongXiangrui ShengJian WuXin ChangTian RenJin CaoTao ChengMingjun WangRheumatoid arthritis (RA) is a progressive autoimmune disease characterized by chronic synovitis and articular destruction. Pain is the earliest and most important symptom. The Janus kinase/stat signaling pathway not only participates in the physiological processes such as the growth and differentiation of normal cells, but also plays a significant role in the pathological mechanisms such as pain in RA patients. Pain in RA patients is mediated by both inflammatory and non-inflammatory factors, including central sensitization and peripheral sensitization. Cytokines can regulate the nociceptor threshold through the JAK pathway, which leads to sensitization. In this review, we provide an overview of the physiological basis of pain modulation, the underlying importance of cytokines and JAK/STAT pathway in pain modulation, and finally introduce the performance of JAK inhibitors in clinical research. Having a better understanding of the mechanism of pain in RA may provide new therapeutic ideas and directions for the clinical improvement of pain in RA patients.https://doi.org/10.1177/1721727X231197498 |
| spellingShingle | Yue Xiong Xiaohui Song Xiangrui Sheng Jian Wu Xin Chang Tian Ren Jin Cao Tao Cheng Mingjun Wang A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis European Journal of Inflammation |
| title | A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis |
| title_full | A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis |
| title_fullStr | A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis |
| title_full_unstemmed | A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis |
| title_short | A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis |
| title_sort | review of janus kinase signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis |
| url | https://doi.org/10.1177/1721727X231197498 |
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