Dynamics of SARS-CoV-2 immunity after vaccination and breakthrough infection in rituximab-treated rheumatoid arthritis patients: a prospective cohort study

Dynamics of SARS-CoV-2 immunity after vaccination and breakthrough infection in rituximab-treated rheumatoid arthritis patients: a prospective cohort study

BackgroundSARS-CoV-2 vaccination in rheumatoid arthritis (RA) patients treated with B cell-depleting drugs induced limited seroconversion but robust cellular response. We aimed to document specific T and B cell immunity in response to vaccine booster doses and breakthrough infection (BTI).MethodsWe...

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Bibliographic Details
Main Authors: Hassen Kared, Ingrid Jyssum, Amin Alirezaylavasani, Ingrid M. Egner, Trung The Tran, Lisa Tietze, Katrine Persgård Lund, Anne Therese Tveter, Sella A. Provan, Hilde Ørbo, Espen A. Haavardsholm, John Torgils Vaage, Kristin Jørgensen, Silje Watterdal Syversen, Fridtjof Lund-Johansen, Guro Løvik Goll, Ludvig A. Munthe
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
T cell
B cell
COVID-19
mRNA vaccination
rheumatoid arthritis
rituximab
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1296273/full

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