Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia
Recent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry. Hypothesizing that the genetic foundation of cognitive ability depends on the broader population-sp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fgene.2019.00888/full |
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| author | Sergey A. Kornilov Sergey A. Kornilov Mei Tan Abdullah Aljughaiman Oxana Yu Naumova Oxana Yu Naumova Elena L. Grigorenko Elena L. Grigorenko Elena L. Grigorenko Elena L. Grigorenko |
| author_facet | Sergey A. Kornilov Sergey A. Kornilov Mei Tan Abdullah Aljughaiman Oxana Yu Naumova Oxana Yu Naumova Elena L. Grigorenko Elena L. Grigorenko Elena L. Grigorenko Elena L. Grigorenko |
| author_sort | Sergey A. Kornilov |
| collection | DOAJ |
| description | Recent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry. Hypothesizing that the genetic foundation of cognitive ability depends on the broader population-specific genetic context, we performed a genome-wide association study and homozygosity mapping of cognitive ability estimates obtained through latent variable modeling in a sample of 354 children from a consanguineous population of Saudi Arabia. Approximately half of the sample demonstrated significantly elevated homozygosity levels indicative of inbreeding, and among those with elevated levels, homozygosity was negatively associated with cognitive ability. Further homozygosity mapping identified a specific run, inclusive of the GRIA4 gene, that survived corrections for multiple testing for association with cognitive ability. The results suggest that in a consanguineous population, a notable proportion of the variance in cognitive ability in the normal range in children might be regulated by population-specific mechanisms such as patterns of elevated homozygosity. This observation has implications for the field’s understanding of the etiological bases of intelligence and its variability around the world. |
| first_indexed | 2024-04-13T05:58:10Z |
| format | Article |
| id | doaj.art-e11f099f920d45cbbf9dd5c7d901ae88 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T05:58:10Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e11f099f920d45cbbf9dd5c7d901ae882022-12-22T02:59:33ZengFrontiers Media S.A.Frontiers in Genetics1664-80212019-09-011010.3389/fgene.2019.00888428766Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi ArabiaSergey A. Kornilov0Sergey A. Kornilov1Mei Tan2Abdullah Aljughaiman3Oxana Yu Naumova4Oxana Yu Naumova5Elena L. Grigorenko6Elena L. Grigorenko7Elena L. Grigorenko8Elena L. Grigorenko9Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, United StatesDepartment of Psychology, University of Houston, Houston, TX, USADepartment of Psychology, University of Houston, Houston, TX, USASpecial Education Department, King Faisal University, Ahsaa, Saudi ArabiaDepartment of Psychology, University of Houston, Houston, TX, USAVavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, RussiaBaylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, United StatesDepartment of Psychology, University of Houston, Houston, TX, USAChild Study Center, Yale University, New Haven, CT, USAMoscow State University for Psychology and Education, Moscow, RussiaRecent studies of the genetic foundations of cognitive ability rely on large samples (in extreme, hundreds of thousands) of individuals from relatively outbred populations of mostly European ancestry. Hypothesizing that the genetic foundation of cognitive ability depends on the broader population-specific genetic context, we performed a genome-wide association study and homozygosity mapping of cognitive ability estimates obtained through latent variable modeling in a sample of 354 children from a consanguineous population of Saudi Arabia. Approximately half of the sample demonstrated significantly elevated homozygosity levels indicative of inbreeding, and among those with elevated levels, homozygosity was negatively associated with cognitive ability. Further homozygosity mapping identified a specific run, inclusive of the GRIA4 gene, that survived corrections for multiple testing for association with cognitive ability. The results suggest that in a consanguineous population, a notable proportion of the variance in cognitive ability in the normal range in children might be regulated by population-specific mechanisms such as patterns of elevated homozygosity. This observation has implications for the field’s understanding of the etiological bases of intelligence and its variability around the world.https://www.frontiersin.org/article/10.3389/fgene.2019.00888/fullintelligencecognitive abilitygenome-wide association studyhomozygosity mappingconsanguinityGRIA4 |
| spellingShingle | Sergey A. Kornilov Sergey A. Kornilov Mei Tan Abdullah Aljughaiman Oxana Yu Naumova Oxana Yu Naumova Elena L. Grigorenko Elena L. Grigorenko Elena L. Grigorenko Elena L. Grigorenko Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia Frontiers in Genetics intelligence cognitive ability genome-wide association study homozygosity mapping consanguinity GRIA4 |
| title | Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia |
| title_full | Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia |
| title_fullStr | Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia |
| title_full_unstemmed | Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia |
| title_short | Genome-Wide Homozygosity Mapping Reveals Genes Associated With Cognitive Ability in Children From Saudi Arabia |
| title_sort | genome wide homozygosity mapping reveals genes associated with cognitive ability in children from saudi arabia |
| topic | intelligence cognitive ability genome-wide association study homozygosity mapping consanguinity GRIA4 |
| url | https://www.frontiersin.org/article/10.3389/fgene.2019.00888/full |
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