In vivo corneal elastography: A topical review of challenges and opportunities
Clinical measurement of corneal biomechanics can aid in the early diagnosis, progression tracking, and treatment evaluation of ocular diseases. Over the past two decades, interdisciplinary collaborations between investigators in optical engineering, analytical biomechanical modeling, and clinical re...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037023001629 |
| _version_ | 1797384101095800832 |
|---|---|
| author | Gongpu Lan Michael D. Twa Chengjin Song JinPing Feng Yanping Huang Jingjiang Xu Jia Qin Lin An Xunbin Wei |
| author_facet | Gongpu Lan Michael D. Twa Chengjin Song JinPing Feng Yanping Huang Jingjiang Xu Jia Qin Lin An Xunbin Wei |
| author_sort | Gongpu Lan |
| collection | DOAJ |
| description | Clinical measurement of corneal biomechanics can aid in the early diagnosis, progression tracking, and treatment evaluation of ocular diseases. Over the past two decades, interdisciplinary collaborations between investigators in optical engineering, analytical biomechanical modeling, and clinical research has expanded our knowledge of corneal biomechanics. These advances have led to innovations in testing methods (ex vivo, and recently, in vivo) across multiple spatial and strain scales. However, in vivo measurement of corneal biomechanics remains a long-standing challenge and is currently an active area of research. Here, we review the existing and emerging approaches for in vivo corneal biomechanics evaluation, which include corneal applanation methods, such as ocular response analyzer (ORA) and corneal visualization Scheimpflug technology (Corvis ST), Brillouin microscopy, and elastography methods, and the emerging field of optical coherence elastography (OCE). We describe the fundamental concepts, analytical methods, and current clinical status for each of these methods. Finally, we discuss open questions for the current state of in vivo biomechanics assessment techniques and requirements for wider use that will further broaden our understanding of corneal biomechanics for the detection and management of ocular diseases, and improve the safety and efficacy of future clinical practice. |
| first_indexed | 2024-03-08T21:31:41Z |
| format | Article |
| id | doaj.art-e120191261eb462285147f45c9978861 |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-03-08T21:31:41Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-e120191261eb462285147f45c99788612023-12-21T07:31:25ZengElsevierComputational and Structural Biotechnology Journal2001-03702023-01-012126642687In vivo corneal elastography: A topical review of challenges and opportunitiesGongpu Lan0Michael D. Twa1Chengjin Song2JinPing Feng3Yanping Huang4Jingjiang Xu5Jia Qin6Lin An7Xunbin Wei8Guangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory, School of Physics and Optoelectronic Engineering, Foshan University, Foshan, Guangdong 528000, China; Weiren Meditech Co., Ltd., Foshan, Guangdong 528000, China; Correspondence to: Foshan University, 18 Jiangwang 1st Rd, Chancheng, Foshan, Guangdong 528000, China.College of Optometry, University of Houston, Houston, TX 77204, United States; Correspondence to: University of Houston, 505 J. Davis Armistead Bldg. 4901 Calhoun Road, Houston, TX 77204-2020, United States.Guangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory, School of Physics and Optoelectronic Engineering, Foshan University, Foshan, Guangdong 528000, ChinaInstitute of Engineering and Technology, Hubei University of Science and Technology, Xianning, Hubei 437100, ChinaGuangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory, School of Physics and Optoelectronic Engineering, Foshan University, Foshan, Guangdong 528000, China; Weiren Meditech Co., Ltd., Foshan, Guangdong 528000, ChinaGuangdong-Hong Kong-Macao Intelligent Micro-Nano Optoelectronic Technology Joint Laboratory, School of Physics and Optoelectronic Engineering, Foshan University, Foshan, Guangdong 528000, China; Weiren Meditech Co., Ltd., Foshan, Guangdong 528000, ChinaWeiren Meditech Co., Ltd., Foshan, Guangdong 528000, ChinaWeiren Meditech Co., Ltd., Foshan, Guangdong 528000, ChinaBiomedical Engineering Department, Peking University, Beijing 100081, China; International Cancer Institute, Peking University, Beijing 100191, China; Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, ChinaClinical measurement of corneal biomechanics can aid in the early diagnosis, progression tracking, and treatment evaluation of ocular diseases. Over the past two decades, interdisciplinary collaborations between investigators in optical engineering, analytical biomechanical modeling, and clinical research has expanded our knowledge of corneal biomechanics. These advances have led to innovations in testing methods (ex vivo, and recently, in vivo) across multiple spatial and strain scales. However, in vivo measurement of corneal biomechanics remains a long-standing challenge and is currently an active area of research. Here, we review the existing and emerging approaches for in vivo corneal biomechanics evaluation, which include corneal applanation methods, such as ocular response analyzer (ORA) and corneal visualization Scheimpflug technology (Corvis ST), Brillouin microscopy, and elastography methods, and the emerging field of optical coherence elastography (OCE). We describe the fundamental concepts, analytical methods, and current clinical status for each of these methods. Finally, we discuss open questions for the current state of in vivo biomechanics assessment techniques and requirements for wider use that will further broaden our understanding of corneal biomechanics for the detection and management of ocular diseases, and improve the safety and efficacy of future clinical practice.http://www.sciencedirect.com/science/article/pii/S2001037023001629Corneal biomechanicsYoung’s modulusElastographyOptical coherence elastographyBrillouin microscopyOcular response analyzer |
| spellingShingle | Gongpu Lan Michael D. Twa Chengjin Song JinPing Feng Yanping Huang Jingjiang Xu Jia Qin Lin An Xunbin Wei In vivo corneal elastography: A topical review of challenges and opportunities Computational and Structural Biotechnology Journal Corneal biomechanics Young’s modulus Elastography Optical coherence elastography Brillouin microscopy Ocular response analyzer |
| title | In vivo corneal elastography: A topical review of challenges and opportunities |
| title_full | In vivo corneal elastography: A topical review of challenges and opportunities |
| title_fullStr | In vivo corneal elastography: A topical review of challenges and opportunities |
| title_full_unstemmed | In vivo corneal elastography: A topical review of challenges and opportunities |
| title_short | In vivo corneal elastography: A topical review of challenges and opportunities |
| title_sort | in vivo corneal elastography a topical review of challenges and opportunities |
| topic | Corneal biomechanics Young’s modulus Elastography Optical coherence elastography Brillouin microscopy Ocular response analyzer |
| url | http://www.sciencedirect.com/science/article/pii/S2001037023001629 |
| work_keys_str_mv | AT gongpulan invivocornealelastographyatopicalreviewofchallengesandopportunities AT michaeldtwa invivocornealelastographyatopicalreviewofchallengesandopportunities AT chengjinsong invivocornealelastographyatopicalreviewofchallengesandopportunities AT jinpingfeng invivocornealelastographyatopicalreviewofchallengesandopportunities AT yanpinghuang invivocornealelastographyatopicalreviewofchallengesandopportunities AT jingjiangxu invivocornealelastographyatopicalreviewofchallengesandopportunities AT jiaqin invivocornealelastographyatopicalreviewofchallengesandopportunities AT linan invivocornealelastographyatopicalreviewofchallengesandopportunities AT xunbinwei invivocornealelastographyatopicalreviewofchallengesandopportunities |