Evaluation of vitamin D levels in allergic and non-allergic asthma
Background and objective: Some researches show that low vitamin D may play a role in asthma pathogenesis. The aim of this study was to evaluate the serum vitamin D level in asthmatics with different phenotypes and to determine its associations with lung function, IgE, eosinophil count and body mass...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-01-01
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| Series: | Medicina |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1010660X15001007 |
| _version_ | 1827853129838755840 |
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| author | Laura Tamašauskienė Edita Gasiūnienė Simona Lavinskienė Raimundas Sakalauskas Brigita Šitkauskienė |
| author_facet | Laura Tamašauskienė Edita Gasiūnienė Simona Lavinskienė Raimundas Sakalauskas Brigita Šitkauskienė |
| author_sort | Laura Tamašauskienė |
| collection | DOAJ |
| description | Background and objective: Some researches show that low vitamin D may play a role in asthma pathogenesis. The aim of this study was to evaluate the serum vitamin D level in asthmatics with different phenotypes and to determine its associations with lung function, IgE, eosinophil count and body mass index (BMI).
Materials and methods: The study population comprised 85 patients with asthma and 73 healthy persons. Patients with asthma were divided into groups according to phenotypes. Allergy was assessed using a skin prick test and measuring eosinophil count in peripheral blood and total IgE in serum. Lung function was evaluated by spirometry. Concentration of vitamin D (25(OH)D3) was measured using a commercial ELISA kit. Smoking history was assessed and BMI was calculated for all individuals.
Results: The vitamin D level was lower in asthmatics than in the control group (14.36 ± 0.57 vs. 22.13 ± 0.84 ng/mL, P < 0.01). There were no significant differences in the vitamin D level between the groups with allergic and non-allergic asthma (14.36 ± 0.77 vs. 14.35 ± 0.74 ng/mL). The low vitamin D level increased the risk of asthma 1.2 times (OR, 1.194; 95% CI, 1.109–1.286, P < 0.01). The vitamin D level did not correlate with lung function and markers of allergy in asthmatic patients. The vitamin D level correlated with FEV1/FVC (rs = 0.72, P < 0.05) in smoking patients with asthma. Correlation between the vitamin D level and BMI was found in all studied subjects (rs = −0.18, P < 0.05).
Conclusions: The vitamin D level was lower in asthmatic patients than in healthy individuals despite their hypersensitivity and increase risk of asthma. There was no relation between the vitamin D level and lung function, eosinophil count and total IgE level, whereas the lower vitamin D level was associated with higher BMI. |
| first_indexed | 2024-03-12T11:01:54Z |
| format | Article |
| id | doaj.art-e1208fecc49e4c35ae3932552cf9d07b |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T11:01:54Z |
| publishDate | 2015-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e1208fecc49e4c35ae3932552cf9d07b2023-09-02T05:36:24ZengMDPI AGMedicina1010-660X2015-01-0151632132710.1016/j.medici.2015.11.003Evaluation of vitamin D levels in allergic and non-allergic asthmaLaura TamašauskienėEdita GasiūnienėSimona LavinskienėRaimundas SakalauskasBrigita ŠitkauskienėBackground and objective: Some researches show that low vitamin D may play a role in asthma pathogenesis. The aim of this study was to evaluate the serum vitamin D level in asthmatics with different phenotypes and to determine its associations with lung function, IgE, eosinophil count and body mass index (BMI). Materials and methods: The study population comprised 85 patients with asthma and 73 healthy persons. Patients with asthma were divided into groups according to phenotypes. Allergy was assessed using a skin prick test and measuring eosinophil count in peripheral blood and total IgE in serum. Lung function was evaluated by spirometry. Concentration of vitamin D (25(OH)D3) was measured using a commercial ELISA kit. Smoking history was assessed and BMI was calculated for all individuals. Results: The vitamin D level was lower in asthmatics than in the control group (14.36 ± 0.57 vs. 22.13 ± 0.84 ng/mL, P < 0.01). There were no significant differences in the vitamin D level between the groups with allergic and non-allergic asthma (14.36 ± 0.77 vs. 14.35 ± 0.74 ng/mL). The low vitamin D level increased the risk of asthma 1.2 times (OR, 1.194; 95% CI, 1.109–1.286, P < 0.01). The vitamin D level did not correlate with lung function and markers of allergy in asthmatic patients. The vitamin D level correlated with FEV1/FVC (rs = 0.72, P < 0.05) in smoking patients with asthma. Correlation between the vitamin D level and BMI was found in all studied subjects (rs = −0.18, P < 0.05). Conclusions: The vitamin D level was lower in asthmatic patients than in healthy individuals despite their hypersensitivity and increase risk of asthma. There was no relation between the vitamin D level and lung function, eosinophil count and total IgE level, whereas the lower vitamin D level was associated with higher BMI.http://www.sciencedirect.com/science/article/pii/S1010660X15001007Vitamin DAsthmaAllergyLung functionBody mass index |
| spellingShingle | Laura Tamašauskienė Edita Gasiūnienė Simona Lavinskienė Raimundas Sakalauskas Brigita Šitkauskienė Evaluation of vitamin D levels in allergic and non-allergic asthma Medicina Vitamin D Asthma Allergy Lung function Body mass index |
| title | Evaluation of vitamin D levels in allergic and non-allergic asthma |
| title_full | Evaluation of vitamin D levels in allergic and non-allergic asthma |
| title_fullStr | Evaluation of vitamin D levels in allergic and non-allergic asthma |
| title_full_unstemmed | Evaluation of vitamin D levels in allergic and non-allergic asthma |
| title_short | Evaluation of vitamin D levels in allergic and non-allergic asthma |
| title_sort | evaluation of vitamin d levels in allergic and non allergic asthma |
| topic | Vitamin D Asthma Allergy Lung function Body mass index |
| url | http://www.sciencedirect.com/science/article/pii/S1010660X15001007 |
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