Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

Site-specific transgene integration in chimeric antigen receptor (CAR) T cell therapies

Abstract Chimeric antigen receptor (CAR) T cells and natural killer (NK) cells are genetically engineered immune cells that can detect target antigens on the surface of target cells and eliminate them following adoptive transfer. Recent progress in CAR-based therapies has led to outstanding clinical...

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Bibliographic Details
Main Authors: Hamed Dabiri, Pooria Safarzadeh Kozani, Mahdi Habibi Anbouhi, Mohadeseh Mirzaee Godarzee, Mohammad Hossein Haddadi, Mohsen Basiri, Vahab Ziaei, Majid Sadeghizadeh, Ensiyeh Hajizadeh Saffar
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Biomarker Research
Subjects:
Chimeric antigen receptor
Cancer immunotherapy
Genome-editing technologies
Retroviral vectors
Natural killer cells
Online Access:https://doi.org/10.1186/s40364-023-00509-1

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