Research progress and applications of epigenetic biomarkers in cancer
Epigenetic changes are heritable changes in gene expression without changes in the nucleotide sequence of genes. Epigenetic changes play an important role in the development of cancer and in the process of malignancy metastasis. Previous studies have shown that abnormal epigenetic changes can be use...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1308309/full |
| _version_ | 1797211843109847040 |
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| author | Jianjun Gao Wujiang Shi Jiangang Wang Canghai Guan Qingfu Dong Jialin Sheng Xinlei Zou Zhaoqiang Xu Yifei Ge Chengru Yang Jiehan Li Haolin Bao Xiangyu Zhong Yunfu Cui |
| author_facet | Jianjun Gao Wujiang Shi Jiangang Wang Canghai Guan Qingfu Dong Jialin Sheng Xinlei Zou Zhaoqiang Xu Yifei Ge Chengru Yang Jiehan Li Haolin Bao Xiangyu Zhong Yunfu Cui |
| author_sort | Jianjun Gao |
| collection | DOAJ |
| description | Epigenetic changes are heritable changes in gene expression without changes in the nucleotide sequence of genes. Epigenetic changes play an important role in the development of cancer and in the process of malignancy metastasis. Previous studies have shown that abnormal epigenetic changes can be used as biomarkers for disease status and disease prediction. The reversibility and controllability of epigenetic modification changes also provide new strategies for early disease prevention and treatment. In addition, corresponding drug development has also reached the clinical stage. In this paper, we will discuss the recent progress and application status of tumor epigenetic biomarkers from three perspectives: DNA methylation, non-coding RNA, and histone modification, in order to provide new opportunities for additional tumor research and applications. |
| first_indexed | 2024-04-24T10:32:55Z |
| format | Article |
| id | doaj.art-e124e97beb4348d0a662fd5ff9e41fae |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T10:32:55Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e124e97beb4348d0a662fd5ff9e41fae2024-04-12T14:49:45ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-04-011510.3389/fphar.2024.13083091308309Research progress and applications of epigenetic biomarkers in cancerJianjun Gao0Wujiang Shi1Jiangang Wang2Canghai Guan3Qingfu Dong4Jialin Sheng5Xinlei Zou6Zhaoqiang Xu7Yifei Ge8Chengru Yang9Jiehan Li10Haolin Bao11Xiangyu Zhong12Yunfu Cui13Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of General Surgery, Tangdu Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaEpigenetic changes are heritable changes in gene expression without changes in the nucleotide sequence of genes. Epigenetic changes play an important role in the development of cancer and in the process of malignancy metastasis. Previous studies have shown that abnormal epigenetic changes can be used as biomarkers for disease status and disease prediction. The reversibility and controllability of epigenetic modification changes also provide new strategies for early disease prevention and treatment. In addition, corresponding drug development has also reached the clinical stage. In this paper, we will discuss the recent progress and application status of tumor epigenetic biomarkers from three perspectives: DNA methylation, non-coding RNA, and histone modification, in order to provide new opportunities for additional tumor research and applications.https://www.frontiersin.org/articles/10.3389/fphar.2024.1308309/fullepigeneticscancerDNA methylationhistone modificationnon-coding RNA |
| spellingShingle | Jianjun Gao Wujiang Shi Jiangang Wang Canghai Guan Qingfu Dong Jialin Sheng Xinlei Zou Zhaoqiang Xu Yifei Ge Chengru Yang Jiehan Li Haolin Bao Xiangyu Zhong Yunfu Cui Research progress and applications of epigenetic biomarkers in cancer Frontiers in Pharmacology epigenetics cancer DNA methylation histone modification non-coding RNA |
| title | Research progress and applications of epigenetic biomarkers in cancer |
| title_full | Research progress and applications of epigenetic biomarkers in cancer |
| title_fullStr | Research progress and applications of epigenetic biomarkers in cancer |
| title_full_unstemmed | Research progress and applications of epigenetic biomarkers in cancer |
| title_short | Research progress and applications of epigenetic biomarkers in cancer |
| title_sort | research progress and applications of epigenetic biomarkers in cancer |
| topic | epigenetics cancer DNA methylation histone modification non-coding RNA |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1308309/full |
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