β-Defensins in the Fight against Helicobacter pylori
Antimicrobial peptides (AMPs) play a pivotal role in the innate immune responses to Helicobacter pylori (Hp) in humans. β-Defensins, a class of cationic arginine-rich AMPs, are small peptides secreted by immune cells and epithelial cells that exert antimicrobial activity against a broad spectrum of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/22/3/424 |
| _version_ | 1818082059810242560 |
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| author | Raffaela Pero Lorena Coretti Ersilia Nigro Francesca Lembo Sonia Laneri Barbara Lombardo Aurora Daniele Olga Scudiero |
| author_facet | Raffaela Pero Lorena Coretti Ersilia Nigro Francesca Lembo Sonia Laneri Barbara Lombardo Aurora Daniele Olga Scudiero |
| author_sort | Raffaela Pero |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) play a pivotal role in the innate immune responses to Helicobacter pylori (Hp) in humans. β-Defensins, a class of cationic arginine-rich AMPs, are small peptides secreted by immune cells and epithelial cells that exert antimicrobial activity against a broad spectrum of microorganisms, including Gram-positive and Gram-negative bacteria and fungi. During Hp infections, AMP expression is able to eradicate the bacteria, thereby preventing Hp infections in gastrointestinal tract. It is likely that gastric β-defensins expression is increased during Hp infection. The aim of this review is to focus on increased knowledge of the role of β-defensins in response to Hp infection. We also briefly discuss the potential use of AMPs, either alone or in combination with conventional antibiotics, for the treatment of Hp infection. |
| first_indexed | 2024-12-10T19:16:05Z |
| format | Article |
| id | doaj.art-e124ec5805d84a6a8a6bc6604e31ce5f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T19:16:05Z |
| publishDate | 2017-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e124ec5805d84a6a8a6bc6604e31ce5f2022-12-22T01:36:36ZengMDPI AGMolecules1420-30492017-03-0122342410.3390/molecules22030424molecules22030424β-Defensins in the Fight against Helicobacter pyloriRaffaela Pero0Lorena Coretti1Ersilia Nigro2Francesca Lembo3Sonia Laneri4Barbara Lombardo5Aurora Daniele6Olga Scudiero7Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II’, 80131 Napoli, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II’, 80131 Napoli, ItalyCEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, ItalyDipartimento di Farmacia, Università degli Studi di Napoli ‘Federico II’, Via Montesano 49, 80131 Napoli, ItalyDipartimento di Farmacia, Università degli Studi di Napoli ‘Federico II’, Via Montesano 49, 80131 Napoli, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II’, 80131 Napoli, ItalyCEINGE-Biotecnologie Avanzate Scarl, Via G. Salvatore 486, 80145 Napoli, ItalyDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II’, 80131 Napoli, ItalyAntimicrobial peptides (AMPs) play a pivotal role in the innate immune responses to Helicobacter pylori (Hp) in humans. β-Defensins, a class of cationic arginine-rich AMPs, are small peptides secreted by immune cells and epithelial cells that exert antimicrobial activity against a broad spectrum of microorganisms, including Gram-positive and Gram-negative bacteria and fungi. During Hp infections, AMP expression is able to eradicate the bacteria, thereby preventing Hp infections in gastrointestinal tract. It is likely that gastric β-defensins expression is increased during Hp infection. The aim of this review is to focus on increased knowledge of the role of β-defensins in response to Hp infection. We also briefly discuss the potential use of AMPs, either alone or in combination with conventional antibiotics, for the treatment of Hp infection.http://www.mdpi.com/1420-3049/22/3/424defensinsHelicobacter pylorigastric diseaseantimicrobial therapy |
| spellingShingle | Raffaela Pero Lorena Coretti Ersilia Nigro Francesca Lembo Sonia Laneri Barbara Lombardo Aurora Daniele Olga Scudiero β-Defensins in the Fight against Helicobacter pylori Molecules defensins Helicobacter pylori gastric disease antimicrobial therapy |
| title | β-Defensins in the Fight against Helicobacter pylori |
| title_full | β-Defensins in the Fight against Helicobacter pylori |
| title_fullStr | β-Defensins in the Fight against Helicobacter pylori |
| title_full_unstemmed | β-Defensins in the Fight against Helicobacter pylori |
| title_short | β-Defensins in the Fight against Helicobacter pylori |
| title_sort | β defensins in the fight against helicobacter pylori |
| topic | defensins Helicobacter pylori gastric disease antimicrobial therapy |
| url | http://www.mdpi.com/1420-3049/22/3/424 |
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